| 王迎春,王金华.ω-3多不饱和脂肪酸对肿瘤细胞侵袭转移的影响及机制研究进展[J].肿瘤学杂志,2016,22(3):236-241. |
| ω-3多不饱和脂肪酸对肿瘤细胞侵袭转移的影响及机制研究进展 |
| Progress on the Effects and Mechanisms of Omega-3 Polyunsaturated Fatty Acids on the Invasion and Metastasis of Tumor Cells |
| 投稿时间：2015-06-16 |
| DOI：10.11735/j.issn.1671-170X.2016.03.B017 |
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| 中文关键词: 多不饱和脂肪酸 肿瘤 侵袭 转移 |
| 英文关键词:polyunsaturated fatty acids neoplasms invasion metastasis |
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| 中文摘要: |
| 摘 要：侵袭与转移是恶性肿瘤的特征性生物学行为，是一个复杂的、多步骤的癌细胞与宿主细胞相互作用的连续过程。ω-3 多不饱和脂肪酸作为被广泛研究的免疫营养物质，不仅在调节机体免疫功能、脂质代谢等方面有着重要作用，而且在肿瘤预防和治疗方面也有着重要作用。 研究表明，ω-3 多不饱和脂肪酸还能诱导多种肿瘤细胞凋亡，并能够在一定程度上抑制其侵袭和转移。文章就ω-3 多不饱和脂肪酸对肿瘤细胞侵袭转移的作用及其机制进行综述。 |
| 英文摘要: |
| Abstract：Invasion and metastasis are the characteristic biological behaviors of malignant tumor，which is a continuous process of cancer cells in a complex，multi-step and host cell interaction. Omega-3 polyunsaturated fatty acids (ω-3PUFA) as widely studied immune nutrients，have important roles in immune regulation and lipid metabolism，etc. ω-3PUFA could induce apoptosis in various tumor cells，and inhibit the invasion and metastasis to a certain extent. In this paper，the influence and mechanisms of ω-3PUFA on invasion and metastasis of tumor cells were reviewed. |
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