| 徐 健,张秀兵,倪 峰.60例肺癌并上腔静脉综合征患者血液中D-二聚体、CEA、CYFRA21-1水平变化及意义[J].肿瘤学杂志,2016,22(3):218-221. |
| 60例肺癌并上腔静脉综合征患者血液中D-二聚体、CEA、CYFRA21-1水平变化及意义 |
| Variation of D-dimer，CEA，CYFRA21-1 levels in Blood of Lung Cancer Patients Complicated with Superior Vena Cava Syndrome and Its Significance |
| 投稿时间：2015-12-21 |
| DOI：10.11735/j.issn.1671-170X.2016.03.B013 |
|
 |
| 中文关键词: 肺肿瘤 上腔静脉综合征 D-二聚体 癌胚抗原 CYFRA21-1 |
| 英文关键词:lung neoplasms superior vena cava syndrome(SVCS) D-dimer carcinoembryonic antigen(CEA） cytokeratin 19 fragment 21-1(CYFRA21-1） |
| 基金项目: |
|
| 摘要点击次数: 1842 |
| 全文下载次数: 738 |
| 中文摘要: |
| 摘 要：［目的］ 探讨肺癌并上腔静脉综合征（superior vena cava syndrome，SVCS）患者血浆D-二聚体、血清CEA、CYFRA21-1水平变化及意义。［方法］ 60例肺癌合并SVCS的Ⅲ、Ⅳ期患者为实验组，60例未合并SVCS的Ⅲ、Ⅳ期患者作为对照组。给予两组患者三维适形放疗联合化疗治疗，检测血D-二聚体水平、血清CEA及CYFRA21-1水平。［结果］ 实验组患者治疗后的血D-二聚体、CEA、CYFRA21-1水平均显著低于治疗前（P<0.05），差异有统计学意义，与对照组比较无显著差异；治疗前实验组患者的D-二聚体、CEA、CYFRA21-1水平均显著高于对照组（P<0.05）。实验组缓解患者的D-二聚体、CEA、CYFRA21-1水平均显著低于未缓解患者（P<0.05）。 ［结论］ 肺癌并SVCS患者血液中具有较高的D-二聚体、CEA、CYFRA21-1水平，三维适形放疗联合化疗治疗能够有效降低其水平，改善患者预后。 |
| 英文摘要: |
| Abstract：［Purpose］ To investigate the changes and significances of level of D-dimer in plasma and serum levels of carcinoembryonic antigen(CEA）and cytokeratin 19 fragment 21-1(CYFRA21-1）in patients with lung cancer complicated with superior vena cava syndrome（SVCS）. ［Methods］ All 120 patients with lung cancer stage Ⅲ/Ⅳ were recruited in the study. Sixty cases with SVCS as the experimental group，and 60 cases without SCVS as control group received three-dimensional conformal radiation therapy combined with chemotherapy. The level of D-dimer in plasma and serum levels of CEA，CYFRA21-1 were detected in all patients. ［Results］ The levels of D-dimer，CEA and CYFRA21-1 in the experimental group after treatment were significantly lower than those before treatment(P<0.05)，but no significant difference were found compared with control group. While before treatment，the levels of D-dimer，CEA and CYFRA21-1 in the experimental group were significantly higher than those in control group(P<0.05).In the experimental group，the levels of D-dimer，CEA and CYFRA21-1 in patients with CR+PR were significantly lower than those in patients with SD+PD (P<0.05). ［Conclusion］ Lung cancer patients complicated with SVCS have high levels of D-dimer，CEA and CYFRA21-1 in blood. Three-dimensional conformal radiation therapy combined with chemotherapy might effectively reduce their levels and improve patients’ prognosis. |
|
在线阅读
查看全文 查看/发表评论 下载PDF阅读器 |