| 陈 旎,张九堂,刘义保.XVMC算法和PB算法在非小细胞肺癌调强放疗中的剂量学比较[J].肿瘤学杂志,2016,22(3):188-193. |
| XVMC算法和PB算法在非小细胞肺癌调强放疗中的剂量学比较 |
| Dosimetric Comparison of X-ray Voxel Monto Carlo and Pencil Beam Dose Calculation Algorithm in Radiation Therapy for Non-small Cell Lung Cancer |
| 投稿时间：2015-08-18 |
| DOI：10.11735/j.issn.1671-170X.2016.03.B007 |
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| 中文关键词: 非小细胞肺癌 调强放疗 放射治疗剂量 |
| 英文关键词:non-small cell cancer intensity modulated radiation therapy radiation dosage |
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| 中文摘要: |
| 摘 要：［目的］ 比较Monaco治疗计划系统中两种不同算法在非小细胞肺癌静态调强放疗中的剂量学差异。［方法］ 选取12例经临床及病理确诊为非小细胞肺癌的患者，采用Monaco计划系统分别为每例患者设计XVMC算法和PB算法两组静态调强放疗计划，优化条件相同，分析比较两组计划的靶区均匀性指数（HI）和适形度指数（CI）以及正常组织的剂量分布。［结果］无论是靶区还是危及器官各项指标，XVMC算法结果均高于PB算法。其中，XVMC算法和PB算法的靶区HI和CI差异分别为1.11%和1.08%，且差异具有统计学意义（P<0.05）；脊髓的最大量以及心脏的各项指标(V10、V20、V30、V40、Dmean)差异均小于2%，差异无统计学意义（P>0.05）；但双肺的各项指标（V5、V10、V20、V30、Dmean）以及食管的V30、V50、Dmean差值均大于2%，且差异具有统计学意义（P<0.05）。XVMC组MU较低，优于PB组（P<0.05）。［结论］ 分析XVMC算法和PB算法的差异原因在于相比于XVMC算法，PB算法未考虑次级电子的输运和能量沉积以及侧向电子失衡，导致计算不精确。因此，在实际的临床计划设计时，对于组织结构密度差异较大、且低密度组织范围较大的部位，建议使用XVMC算法进行剂量计算。 |
| 英文摘要: |
| Abstract：［Purpose］ To compare the dosimetric differences between pencil beam(PB) and X-ray voxel Monte Carlo(XVMC) in Monaco treatment planning system in intensity modulated radiation therapy (IMRT) for non-small cell lung cancer(NSCLC). ［Methods］ PB and XVMC plans were designed for 12 cases with NSCLC by using different algorithm of Monaco treatment planning system. Plans were compared in terms of conformity index，homogeneity index of target volume and receiving dose to organ at risk. ［Results］ The dose calculated by XVMC algorithm was higher than that by PB algorithm no matter for organs at risk or target. Specifically，the differences for conformity and homogeneity of PTV were 1.11% and 1.08%，respectively，and the difference was significantly different(P<0.05).For the maximum dose of spinal cord and heart (V10，V20，V30，V40，Dmean)，there was no significance difference(P>0.05) for each index between PB algorithm and XVMC algorithm and the difference variance was within 2%. However，for the esophagus （V30，V50，Dmean）and Lung(V5，V10，V20，V30、Dmean)，the differences between PB algorithm and XVMC algorithm had significant difference，which exceeded 2% in numerical. XVMC had lower MU，which was superior than PB group(P<0.05) .［Conclusion］ The main reason of differences between XVMC and PB algorithm was that XVMC algorithm considering the secondary electron transport and energy deposition and lateral electronic balance with comparison of PB algorithm. For cases with areas including many low density tissues，XVMC algorithm is recommended for dose calculation. |
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