| 宫玉蕾,郝长城.小细胞肺癌组织中CD151的表达及临床意义[J].肿瘤学杂志,2016,22(3):184-187. |
| 小细胞肺癌组织中CD151的表达及临床意义 |
| Expression of CD151 in Small Cell Lung Cancer and Its Clinical Significance |
| 投稿时间：2015-08-01 |
| DOI：10.11735/j.issn.1671-170X.2016.03.B006 |
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| 中文关键词: 小细胞肺癌 CD151 免疫组织化学 临床病理学 |
| 英文关键词:small cell lung cancer CD151 immunohistochemistry clinicopathology |
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| 中文摘要: |
| 摘 要：［目的］ 探讨小细胞肺癌（SCLC）组织中CD151的表达水平及其临床意义。［方法］ 免疫组化SP法检测82例SCLC组织与20例癌旁组织中CD151的表达情况，并结合临床资料进行分析。［结果］ SCLC组织中CD151阳性表达率明显高于癌旁肺组织（χ2=22.274，P=0.034）。CD151蛋白表达与SCLC患者年龄、性别、是否吸烟等无明显相关性（P>0.05），局限期与广泛期的阳性表达率之间没有明显差异（χ2=0.113，P=0.737），但局限期与广泛期SCLC组织中CD151的阳性表达率均高于癌旁组织（χ2分别为11.123、14.391，P分别为0.001、0.000）。CD151阴性表达的患者1年生存率明显高于阳性表达者（χ2=5.637，P=0.018）。Kaplan-Meier分析提示CD151阴性表达者生存期显著高于阳性表达者（χ2=20.584，P=0.000）。［结论］ CD151的阳性表达可能与SCLC的发生及早期转移有关；CD151的检测可用于对SCLC患者生存时间的评估，可能会成为预估其预后的一项重要指标。 |
| 英文摘要: |
| Abstract：［Purpase］ To investigate the expression level of CD151 in small cell lung cancer(SCLC) and its clinical significance. ［Methods］ Immunohistochemical SP staining was used to detect the expression of CD151 in 82 cases with SCLC and 20 cases of cancer adjacent tissues. ［Results］ The positive expression rate of CD151 in SCLC was significantly higher than that in cancer adjacent tissue(χ2=22.274，P=0.034). The expression level of CD151 in SCLC had no significant relation with patients’ age，gender，smoking(P>0.05)，and also there was no significant difference between limited disease and extensive disease(χ2=0.113，P=0.737)，but the expression of CD151 in cancer tissues of limited disease and extensive disease was higher than that in cancer adjacent tissues(χ2=11.123，14.391；P=0.001，0.000). 1-year survival in patients with negative expression of CD151 was significantly higher than that in the positive patients（χ2=5.637，P=0.018）. Kaplan-Meier analysis showed that survival rate of negative expression patients was higher than that of the positive expression patients (χ2=20.584，P=0.000).［Conclusion］ CD151 protein expression might be related to the carcinogenesis and earlier metastasis of SCLC. CD151 protein assay might be used to evaluate the survival of SCLC patients，and might become an important indicator of prognosis. |
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