| 孙宗文,张 妍.颅脑放疗联合替莫唑胺治疗非小细胞肺癌脑转移30例[J].肿瘤学杂志,2016,22(1):53-56. |
| 颅脑放疗联合替莫唑胺治疗非小细胞肺癌脑转移30例 |
| Whole Brain Radiotherapy Combined with Temozolomide in the Treatment of 30 Cases with Brain Metastasis from Non-small Cell Lung Cancer |
| 投稿时间：2015-09-16 |
| DOI：10.11735/j.issn.1671-170X.2016.01.B011 |
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| 中文关键词: 非小细胞肺癌 脑肿瘤 肿瘤转移 放射疗法 替莫唑胺 |
| 英文关键词:non-small cell lung cancer brain neoplasms neoplasm metastasis radiotherapy temozolomide |
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| 摘要点击次数: 1851 |
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| 中文摘要: |
| 摘 要：［目的］ 观察全脑放疗与全脑放疗联合替莫唑胺治疗非小细胞肺癌(non-small cell lung cancer，NSCLC)脑转移的疗效、生存时间及不良反应。［方法］ 60例NSCLC伴脑转移患者随机分为放射治疗组(放疗组30例)和放射治疗联合化疗组(联合组30例)。放疗组：全脑放疗剂量DT 40Gy/20F/4W。联合组：放疗方法与放疗组相同，放疗同步替莫唑胺治疗剂量为75mg/（m2·d），d1~28。［结果］ 放疗组和联合组总有效率分别为43.3％(13/30)、63.3％(19/30) (P=0.07)；中位生存时间放疗组为4.3个月，联合组为8.5个月(P<0.01)。联合组骨髓抑制和胃肠反应高于放疗组（P＞0.05）。［结论］ 全脑放疗联合替莫唑胺可以作为NSCLC脑转移患者的治疗选择，治疗不良反应可耐受。 |
| 英文摘要: |
| Abstract：［Purpose］ To investigate the therapeutic effect，survival and toxicity of whole brain radiotherapy alone or radiotherapy combined with temozolomide (TMZ) in the treatment of brain metastases from non-small cell lung cancer(NSCLC). ［Methods］ Sixty NSCLC patients with brain metastasis were randomly divided into radiotherapy group (30 cases) and chemoradiotherapy group (combination group，30 cases)：radiotherapy group with whole brain conventional radiotherapy dose DT40Gy/20F/4W；combination group with the same radiation method as the radiotherapy group，concurrent with TMZ dose of 75 mg/(m2·d)，d1～28. ［Results］ The response rate of radiotherapy group and combination group was 43.3%(13/30) and 63.3%(19/30)(P=0.07) respectively；and the median survival was 4.3 months and 8.5 months(P<0.01) respectively. Bone marrow suppression and gastrointestinal toxicities in combination group were higher than those in the radiotherapy group（P＞0.05）. ［Conclusion］ Whole brain radiotherapy combined with TMZ might be used as a treatment option for NSCLC patients with brain metastasis，with tolerable toxicities. |
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