| 李 玉,张素静,刘小亮.立体定向放射治疗50例早期原发性肝癌临床疗效观察[J].肿瘤学杂志,2016,22(1):49-52. |
| 立体定向放射治疗50例早期原发性肝癌临床疗效观察 |
| Clinical Response of Stereotactic Radiotherapy in 50 Cases with Primary Liver Cancer at Early Stage |
| 投稿时间：2015-07-01 |
| DOI：10.11735/j.issn.1671-170X.2016.01.B010 |
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| 中文关键词: 肝肿瘤 射波刀 疗效 不良反应 |
| 英文关键词:liver neoplasms CyberKnife curative effect toxicity |
| 基金项目: |
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| 中文摘要: |
| 摘 要：［目的］ 评价射波刀立体定向放射治疗技术治疗早期原发性肝癌的短期疗效和不良反应。［方法］ 对50例无法进行手术切除或拒绝手术治疗的早期原发性肝癌行射波刀立体定向放射治疗。肿瘤直径0.6～5.0cm，单次分割剂量4～12Gy，照射次数为3～8次，肿瘤剂量（PTV）36～57Gy，连续照射。［结果］ 随访13～51个月，完全缓解（CR）41例(82.0%)，部分缓解（PR）8例(16.0%)，稳定（SD）0例，进展（PD）1例（2.0%），有效率（CR+PR）为98.0%，1、2、3年总生存率为100.0%、90.0%、76.0%。［结论］ 射波刀是治疗早期肝癌较有效的手段，且不良反应较小。 |
| 英文摘要: |
| Abstract：［Purpose］To evaluate the short-term response and toxicity of CyberKnife on the patients with primary liver cancer at early stage who never accept surgical resection.［Methods］ Fifty cases with primary liver cancer at early stage who were not able to accept surgery or reject the surgery underwent CyberKnife treatment. The diameter of tumor ranged from 0.6 to 5.0 cm，the dose of each irradiation was between 4～12Gy，the number of fractions was 3～8，and the planning target volume (PTV) ranged from 36 to 57 Gy. Continuous irradiation was carried out.［Results］A short-term follow-up of 13～51 months was done. Complete response(CR) achieved in 41 cases (82.0%)，partial response(PR) in 8 cases (16.0%)，no case in stable disease(SD)，progression disease(PD) in 1 case(2.0%). The response rate(CR+PR) was 98.0%.The 1-，2- and 3-year survival rates were 100.0%，90.0%，and 76.0% respectively.［Conclusion］CyberKnife is an effective way to treat the primary liver cancer at early stage with low toxicity. |
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