| 石鹏飞,张晓明,刘宝刚.替吉奥同期调强放疗对高龄晚期食管鳞癌患者的影响[J].肿瘤学杂志,2016,22(1):45-48. |
| 替吉奥同期调强放疗对高龄晚期食管鳞癌患者的影响 |
| The Effect of S-1 Concomitant with Intensity Modulated Radiation Therapy in the Treatment for Elderly Advanced Esophageal Squamous Cell Carcinoma |
| 投稿时间：2015-09-23 |
| DOI：10.11735/j.issn.1671-170X.2016.01.B009 |
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| 中文关键词: 替吉奥 调强放疗 食管肿瘤 鳞状细胞癌 近期疗效 |
| 英文关键词:S-1 intensity modulated radiation therapy(IMRT) esophageal neoplasms squamous cell carcinoma short-term response |
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| 摘要点击次数: 1674 |
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| 中文摘要: |
| 摘 要：［目的］ 探讨替吉奥同期调强放疗对高龄晚期食管鳞癌患者的近期疗效和安全性。［方法］高龄晚期食管鳞癌患者100例，随机分为两组，每组50例，所有患者均采用全程调强适形放射治疗(IMRT)，治疗组在此基础上同时于放疗第1 d 开始口服替吉奥胶囊治疗，化疗3个周期后观察两组患者近期疗效，同时记录患者的1年生存率、局部控制率及生存时间以及不良反应发生率。［结果］ 两组患者治疗后，治疗组的近期有效率达84.00%，对照组的近期有效率仅为62.00%，治疗组的近期疗效优于对照组，差异有统计学意义（P<0.05）；两组患者治疗后，治疗组的1年生存率、局部控制率、平均生存时间均明显高于对照组（P<0.05）；不良反应发生率两组无明显差异（P>0.05）。［结论］ 对高龄晚期食管鳞癌患者应用替吉奥同期调强放疗治疗，近期疗效好，不良反应未增加，值得临床推广。 |
| 英文摘要: |
| Abstract：［Purpose］ To investigate the short-term response and safety of S-1 concomitant with intensity modulated radiation therapy(IMRT) in the treatment for elderly advanced esophageal squamous cell carcinoma(ESCC). ［Methods］ One hundred ESCC patients were divided into two groups，each group with 50 cases. All patients were applied with IMRT treatment，and the treatment group was applied with S-1 capsule in addition. After 3 cycles of chemotherapy，the short-term response，1-year survival rate，local control rate，survival and toxicity were recorded. ［Results］ The short-term response rate of treatment group was 84.00%，which was significantly higher than that in the control group(62.00%，P<0.05). The 1-year survival rate，local control rate and survival of treatment group were much higher than those in the control group (P<0.05). The rate of toxicity between two groups has no statistically difference (P>0.05). ［Conclusion］ S-1 concomitant with IMRT has superior short-term response and less toxicity in the treatment for elderly advanced ESCC. |
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