| 王 维,王 林.骨存储生长因子在肿瘤骨转移中的作用[J].肿瘤学杂志,2015,21(12):1015-1018. |
| 骨存储生长因子在肿瘤骨转移中的作用 |
| The Role of Bone-stored Growth Factors in Bone Metastasis Tumor |
| 投稿时间：2015-03-29 |
| DOI：10.11735/j.issn.1671-170X.2015.12.B014 |
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| 中文关键词: 肿瘤 骨转移 骨存储生长因子 |
| 英文关键词:tumor bone metastasis bone-stored growth factors |
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| 摘要点击次数: 2010 |
| 全文下载次数: 788 |
| 中文摘要: |
| 摘 要：骨存储生长因子又称骨源性生长因子，是大量存在于骨中的一系列生长因子。这些生长因子由存在于骨中的细胞分泌，正常情况下维持稳态，发生骨转移时，一方面癌细胞分泌骨存储生长因子，另一方面癌细胞影响骨中其他细胞分泌骨存储生长因子，都会造成骨存储生长因子分泌量失衡。其中一些骨存储生长因子失衡，如转化生长因子-β和胰岛素样生长因子分泌量增加，其可加速溶骨性损害。近年来，随着对肿瘤转移微环境研究的加深，骨存储生长因子成为研究热点，为了加深对这些生长因子作用机制的了解，本文就目前骨存储生长因子与肿瘤骨转移的研究进展作一综述。 |
| 英文摘要: |
| Abstract：Bone is a storehouse of a variety of growth factors，which are called bone-stored growth factors or bone-derived growth factors. These growth factors secrete by the cells in the bone，which maintain homeostasis under normal circumstances. Both cancer cells and other stromal cells can secrete bone-stored growth factors after bone metastasis. The above action will all lead to inner imbalance of bone growth factor secretion. Imbalance of bone-stored growth factors，such as the increasing production of transforming growth factor beta and insulin-like growth factor，which can accelerate osteolytic damage. In recent years，with the deepening of research on tumor metastasis microenvironment，bone-stored growth factors become the hot spot. In order to have a further understanding of the mechanism of these growth factors，we focus on the bone-stored growth factors and current knowledge of bone metastases tumor in this review. |
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