| 王 华,李 嶔,应霁翀.磁共振成像在鉴别诊断肝脏局灶性结节增生与小肝细胞癌中的应用价值[J].肿瘤学杂志,2015,21(12):999-1003. |
| 磁共振成像在鉴别诊断肝脏局灶性结节增生与小肝细胞癌中的应用价值 |
| The Application of MRI on the Differentiation of Small Hepatocellular Carcinoma and Focal Nodular Hyperplasia |
| 投稿时间：2015-08-14 |
| DOI：10.11735/j.issn.1671-170X.2015.12.B011 |
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| 中文关键词: 癌，肝细胞 肝疾病 结节病 磁共振成像 诊断，鉴别 |
| 英文关键词:carcinoma,hepatocellular liver diseases sarcoidosis magnetic resonance imaging diagnosis,differential |
| 基金项目: |
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| 摘要点击次数: 2033 |
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| 中文摘要: |
| 摘 要：［目的］ 探讨肝脏局灶性结节增生（FNH）和小肝细胞癌 （SHCC）在MRI平扫、增强扫描和 DWI参数上的差异。［方法］ 选取SHCC 及FNH患者57例。分析 MRI 鉴别 SHCC 与 FNH 的平扫、增强扫描和 DWI、曲线下面积（AUC）等参数差异。［结果］ 在T1WI表现上，FNH 等信号病灶12个（57.14%），SHCC低信号病灶37个（84.09%）；在动态增强门静脉期 T1WI表现上，FNH 高信号病灶15个（71.43%），SHCC低信号病灶26个（59.09%），2组信号等级分类差异具有统计学意义（Z=－4.518、－5.723，P<0.05）；在T2WI 和 DWI表现上，2组病灶均以高信号为主，差异不具有统计学意义（Z=－1.318、－1.431，P>0.05）。T1WI的ROC 曲线下面积为0.698，特异性为81.4%，灵敏度为58.7%；多期动态增强门静脉T1WI的ROC 曲线下面积为0.892，特异性和灵敏度分别为61.0%和100.0%。［结论］ SHCC 与FNH的鉴别诊断中MRI 平扫T1WI 和多期动态增强门静脉期 T1WI的诊断价值较高，而DWI 和T2WI 对鉴别诊断能起到一定辅助作用。 |
| 英文摘要: |
| Abstract：［Purpose］ To analysis MRI plain scan，multiphase contrast enhanced scan and diffusion weighted imaging (DWI) in differential diagnosis of small hepatocellular carcinoma (SHCC) and focal nodular hyperplasia (FNH). ［Method］ A total of 57 cases of patients in SHCC or FNH were selected to analysis the MRI plain scan，multiphase contrast enhanced scan and DWI，the area under the curve(AUC)，sensitivity and specificity. ［Results］ On T1WI sequence in plain scan，there were 12 iso-signal lesions(57.14%) in FNH and 37(84.09%) low-signal lesions in SHCC，on dynamic enhancement in portal vein phase T1WI，there were 15 high-signal lesions (71.43%) on FNH and 26 (59.09%) low-signal lesions in SHCC，with statistically significant diffe-rences(Z=-4.518，-5.723，P<0.05).In the T2WI and DWI，there were mainly high-signal lesions in 2 groups，with no statistically significant (Z=-1.318，-1.431，P>0.05). The AUC of T1WI in diffe-rentiating SHCC and FNH was 0.698，whose sensitivity and specificity were 81.4% and 58.7%. The AUC of dynamic enhancement in portal vein phase T1WI was 0.892，whose sensitivity and specificity were 61.0% and 100%. ［Conclusions］ There are high values in the differential diagnosis of SHCC and FNH by 3.0T MRI plain scan T1WI and multi-phase dynamic enhancement，and DWI and T2WI can play a supporting role in it. |
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