| 王文鹏,黄光磊,薛英威.胃腺癌脉管浸润的临床病理特征及预后分析[J].肿瘤学杂志,2015,21(12):988-992. |
| 胃腺癌脉管浸润的临床病理特征及预后分析 |
| Analysis of Clinicopathological Features and Prognosis of Patients with Gastric Adenocarcinoma in Lymphatic Vessel and/or Venules Invasion |
| 投稿时间：2015-08-21 |
| DOI：10.11735/j.issn.1671-170X.2015.12.B009 |
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| 中文关键词: 胃腺癌 淋巴管 微静脉 淋巴结转移 预后 |
| 英文关键词:gastric adenocarcinoma lymphaticvessel venules lymph node metastasis prognosis |
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| 中文摘要: |
| 摘 要：［目的］探讨胃腺癌根治术后脉管浸润患者的临床病理特征及预后。［方法］回顾性分析行胃癌根治术的192例患者的临床病理资料，按脉管是否浸润分为两组：脉管浸润组［LV（＋）组］47例和脉管未浸润组［LV（－）组］145例，分别比较其临床病理特征及预后差异。［结果］脉管浸润组和脉管未浸润组在年龄、肿瘤大小、大体类型、pT分期、pN分期、病理分期及手术方式方面差异均具有统计学意义（P<0.05），尤其与pN分期之间显著相关（P=0.007）。但在性别、肿瘤部位、组织分化程度上差异无统计学意义（P>0.05）。单因素生存分析显示，脉管浸润组3年生存率为27.7%，脉管未浸润组3年生存率56.6%，两者相比差异具有统计学意义（P<0.001）。进一步探讨脉管浸润与淋巴结转移的关系发现，脉管浸润伴随淋巴结转移者3年生存率21.4%，脉管未浸润伴随淋巴结转移者3年生存率45.1%，差异具有统计学意义（P<0.001）。多因素生存分析显示，脉管浸润（P=0.040，OR=1.595）、pT分期（P<0.001，OR=1.721）和pN分期（P=0.006，OR=1.354）是影响胃腺癌患者预后的独立因素。［结论］胃腺癌脉管浸润与淋巴结转移显著相关。脉管浸润的胃腺癌患者预后差，当脉管浸润伴随淋巴结转移时提示要比单纯的淋巴结转移预后更差。脉管浸润是影响胃腺癌患者预后的独立因素。 |
| 英文摘要: |
| Abstract：［Purpose］To investigate the differences in clinicopathological features and prognosis of lymphatic vessel and/or venules invasion after radical gastrectomy.［Methods］ Clinicopathological data of 192 patients with gastric adenocarcinoma undergone radical gastrectomy were analyzed retrospectively. These patients were divided into two groups whose differences were compared by clinicopathological features and prognosis：47 patients with lymphatic vessel and/or venules invasion［group LV（＋）］，145 patients without lymphatic vessel and/or venules invasion［group LV（－）］.［Results］ There were statistic differences between two groups in age，lesionsize，subtypes，pT classification，TNM stage，operation(P<0.05)and particularly in pN classification(P=0.007).Whereas，there was no statistic difference in gender，lesion location(P>0.05).Univariate survival analysis showed that the differences were statistically significant between the group invaded ［group LV(+)］ whose three year survival rate was 27.7% and the other group by no invasion ［group LV(-)］ whose three year survival rate was 56.6%(P<0.001).To further exoplore the relationship between lymphatic vessel and/or venules invasion(LV)and lymph node(LN)，we found that there was statistically significance between lymphatic vessel and/or venules invasion associated with lymph node metastasis［group LV(+) LN(+)］ whose three year survival rate was 45.1% and lymphatic vessel and/or venules invasion not associated with lymph node metastasis［group LV (-) LN(+)］ whose three year survival rate was 21.4%(P<0.001).Multivariate survival analysis showed that lymphatic vessel and/or venules invasion（LV+）（P=0.040，OR=1.595），pT classification（P<0.01，OR=1.721）and pN（P=0.006，OR=1.354）classification were the independent prognostic factors of patients with gastric adenocarcinoma. ［Conclusions］ Lymphatic vessel and/or venules invasion of gastric adenocarcinoma is significantly associated with lymph node metastasis. The prognosis of lymphatic vessel and venules invasion is poor. Lymphatic vessel and/or venules invasion simultaneously accompanied by lymph node metastasis might prompt a worse prognosis than lymph node metastasis simply. Lymphatic vessel and/or venules invasion is an independent prognostic factor of patients with gastric adenocarcinoma. |
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