| 周 超,杨海华,周丽珍.局部晚期食管癌术前放化疗加联合胸腹腔镜下根治术术前放疗靶区的临床研究[J].肿瘤学杂志,2015,21(12):961-967. |
| 局部晚期食管癌术前放化疗加联合胸腹腔镜下根治术术前放疗靶区的临床研究 |
| Clinical Research of Radiotherapy Target for Neo-adjuvant Chemoradiotherapy Followed by Combined Thoracoscopic and Laparoscopic Minimal Invasive Esophagectomy in Locally Advanced Esophageal Cancer |
| 投稿时间：2015-07-05 |
| DOI：10.11735/j.issn.1671-170X.2015.12.B004 |
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| 中文关键词: 食管肿瘤 放射治疗 化学药物治疗 腔镜手术 靶区递增试验 |
| 英文关键词:esophageal neoplasms radiotherapy chemotherapy minimal invasive esophagectomy target volume escalation study |
| 基金项目:浙江省重大科技专项重点社会发展项目（2011C13039-2）；2012年恩泽医疗集团科研项目基金（12EZD56） |
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| 中文摘要: |
| 摘 要：［目的］ 探讨局部晚期食管癌术前放化疗联合胸腹腔镜下食管癌根治术术前放疗的最佳靶区范围及方案的安全性、有效性。［方法］ 前瞻性收集39例局部晚期食管癌患者，通过靶区范围递增试验（分累及野组、胸廓入口组、扩大野组）确立术前放疗最佳放疗靶区并评价临床疗效及不良反应。 ［结果］ 通过靶区递增试验确定最大范围靶区为胸廓入口组。胸廓入口组的放化疗相关3度以上不良反应有骨髓抑制（81.81%）、消化道反应（3.03%）、放射性食管炎（3.03%）、手术相关并发症以术后肺部感染（23.33%）为主。R0切除率为97.44%，pCR率为51.28%，1年生存率为86.67%，2年生存率为61.34%。［结论］ 局部晚期食管癌术前放疗靶区胸廓入口最佳且安全有效。 |
| 英文摘要: |
| Abstract：［Purpose］ To investigate the optimum radiotherapy target volume for neo-adjuvant chemoradiotherapy followed by combined thoracoscopic and laparoscopic minimal invasive esophagectomy as well as the safety and short-term efficacy in the treatment of local advanced esophageal cancer．［Methods］ Thirty-nine patients with local advanced esophageal cancer were enrolled in this trial．The maximum radiotherapy target volume was determined by target volume escalation study，and the short-term efficacy and toxicities were evaluated. ［Results］ The maximum target volume was superior aperture of thorax field by the target volume escalation study. In this regimen，the grade 3 or serious toxicities for chemoradiotherapy included bone marrow suppression (81.81%)，gastrointestinal reactions (3.03%) and radiation esophagitis(3.03%). The majority postoperative complication was pulmonary infection (23.33%). Rates of complete resection，pCR，1- year and 2- year survival rate were 97.44%，51.28%，86.67%，61.34%，respectively. ［Conclusion］ The regimen of superior aperture of thorax field for neo-adjuvant chemoradiotherapy followed by combined thoracoscopic and laparoscopic minimal invasive esophagectomy is safe and effective in treatment of local advanced esophageal cancer. |
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