| 王世东,陈祖华,宋启斌.食管癌的全基因组关联研究进展[J].肿瘤学杂志,2015,21(11):922-927. |
| 食管癌的全基因组关联研究进展 |
| Research Progress in Genome-wide Association Studies of Esophagus Cancer |
| 投稿时间：2014-10-06 |
| DOI：10.11735/j.issn.1671-170X.2015.11.B013 |
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| 中文关键词: 全基因组关联研究 食管肿瘤 单核苷酸多态性 拷贝数变异 |
| 英文关键词:genome-wide association study esophageal neoplasms single nucleotide polymorphism copy number variation |
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| 摘要点击次数: 1932 |
| 全文下载次数: 776 |
| 中文摘要: |
| 摘 要：基因—环境和基因—基因交互作用在食管癌发生发展中起着重要作用。全基因组关联研究(genome-wide association study，GWAS)已发现一些与食管癌相关的易感位点和区域，为食管癌的预防和诊治提供了新的思路和方向。文章对近几年来关于食管癌的GWAS进展进行综述，分析GWAS在食管癌研究中的优点和应用前景。 |
| 英文摘要: |
| Abstract：Gene-gene and gene-environment interaction play important roles in the pathogenesis of esophageal cancer. Gnome-wide association study(GWAS) have discovered a series of susceptibility genes and loci which provide us new strategies for the prevention，diagnosis and treatment of esophageal cancer. In this article，the progress in GWAS of esophageal cancer is reviewed，and the advantages as well as the perspective of its application are discussed. |
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