| 张 翔,周云海,姚路斌.PCBP1在140例结直肠癌中的表达及临床意义[J].肿瘤学杂志,2015,21(11):908-912. |
| PCBP1在140例结直肠癌中的表达及临床意义 |
| Expression of PCBP1 in 140 Cases with Colorectal Cancer and Its Clinical Significance |
| 投稿时间：2015-09-28 |
| DOI：10.11735/j.issn.1671-170X.2015.11.B010 |
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| 中文关键词: 多聚胞嘧啶结合蛋白-1（PCBP1） 结直肠肿瘤 免疫组织化学 预后 临床病理学 |
| 英文关键词:poly (C)-binding protein 1(PCBP1） colorectal neoplasms immunohistochemistry prognosis |
| 基金项目: |
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| 摘要点击次数: 2010 |
| 全文下载次数: 893 |
| 中文摘要: |
| 摘 要：［目的］ 研究多聚胞嘧啶结合蛋白-1（poly (C)-binding protein 1，PCBP1）在结直肠癌（colorectal cancer，CRC）组织中的表达及其临床意义。［方法］ 采用免疫组织化学技术（EnVision法）检测140例CRC组织及相对应140例癌旁肠黏膜组织中PCBP1的表达情况，使用卡方检验分析PCBP1的表达与CRC患者的临床病理参数之间的关系，Kaplan-Meier生存曲线分析及Cox多因素分析PCBP1的表达对CRC患者预后的影响。［结果］ PCBP1在CRC组织的阳性率为37.1%（52/140），明显低于癌旁结直肠组织的52.1%（73/140）；PCBP1的表达情况与肿瘤TNM分期及淋巴结转移相关；Cox多因素回归分析结果显示，PCBP1表达、TNM分期及术后辅助治疗与CRC的预后相关；Kaplan-Meier生存曲线结果表明PCBP1低表达的病例预后较高表达的病例差，差异具有统计学意义（P=0.001）。［结论］ PCBP1在CRC组织中低表达，其表达失调与CRC的发生、发展及预后有密切关系。 |
| 英文摘要: |
| Abstract：［Purpose］ To investigate the expression of poly (C)-binding protein 1(PCBP1）in colorectal cancer(CRC） and its clinical significance. ［Methods］ Immunohistochemistry (IHC) was used to detect the expression of PCBP1 in 140 cases of CRC tissues and their adjacent tissues. Pearson χ2 test was performed to analyze the association of PCBP1 expression with clinicopathologic features. Kaplan-Meier analysis and Cox regression analysis were used to evaluate the influence of PCBP1 expression on the prognosis of CRC patients. ［Results］ The positive rate of PCBP1 expression in CRC was 37.1%(52/140)，which was significantly lower than that(52.1%，73/140) in adjacent tissues. The expression of PCBP1 was associated with TNM staging and lymph node metastasis.Multivariate analysis using the Cox proportional hazards model demonstrated that the expression of PCBP1 as well as TNM staging and adjuvant treatment after surgery were independent prognostic factors of overall survival. The result of Kaplan-Meier analysis showed that patients with low expression of PCBP1 had poor overall survival rate (P=0.001). ［Conclusion］ PCBP1 expression is down-regulated in CRC tissue，and its expression dysregulation is associated with carcinogenesis and prognosis of CRC. |
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