| 施 震,周 翔.长期饮酒患者结肠肿瘤术后舒芬太尼镇痛效果观察[J].肿瘤学杂志,2015,21(11):904-907. |
| 长期饮酒患者结肠肿瘤术后舒芬太尼镇痛效果观察 |
| Effect of Chronic Alcohol Intake on the Postoperative Analgesic Effect of Sufentanil in Colon Cancer Patients |
| 投稿时间：2015-07-20 |
| DOI：10.11735/j.issn.1671-170X.2015.11.B009 |
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| 中文关键词: 结肠肿瘤 舒芬太尼 饮酒 镇痛 |
| 英文关键词:colon neoplasms sufentanil alcohol drinking analgesia |
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| 中文摘要: |
| 摘 要：［目的］ 观察长期饮酒对腹腔镜结肠肿瘤切除患者术后阿片类药物镇痛效果的影响。［方法］ 选择择期行腹腔镜结肠肿瘤切除术患者60例，按照患者是否长期饮酒分为长期饮酒组与对照组。全麻术后予以静脉镇痛泵镇痛（舒芬太尼2.5μg/kg +托烷司琼4mg），术后记录所有患者镇痛泵的实际按压次数与有效按压次数，并采取视觉模拟评分法（VAS）评估患者不同时间段的疼痛程度。并记录所有患者恶心呕吐、呼吸抑制、低血压等不良事件的发生。［结果］ 长期饮酒组患者镇痛泵的实际按压次数和有效按压次数均显著高于对照组，术后各时间点VAS评分亦较对照组显著增高；两组患者恶心呕吐、低血压发生率无统计学差异，且均未出现呼吸抑制现象。［结论］ 在相同的条件下，长期饮酒组患者术后阿片类药物镇痛效果差，需要更大剂量的阿片类药物才能满意的镇痛效果。 |
| 英文摘要: |
| Abstract：［Purpose］ To observe the effect of chronic alcohol intake on the postoperative analgesic effect of sufentanil in colon cancer patients undergoing laparoscopic surgery.［Methods］ Sixty cases with colon cancer undergoing selective laparoscopic radical surgery were divided into chronic alcohol intake group and control group according to the history of chronic alcohol intake. All the patients used intravenous analgesia pump(sufentanil 2.5μg/kg with tropisetron 4mg) for postoperative analgesia. The times of pressing pump demanded and effectively，the incidence of nausea and vomiting，respiratory depression，hypotension and other adverse effects were all recorded. Also，the degree of pain at different times were estimated with visual analogue scale（VAS）. ［Results］ The demanded press times，effective press times of analgesia pump，the VAS score at different times in chronic alcohol intake group were all significantly higher than those of control group. There was no statistical difference in the incidence of nausea and vomiting，hypotension and respiratory depression between the two groups. ［Conclusion］ Under the same condition，the analgesic effect of sufentanil in chronic alcohol intake patients decreases，and more analgesic drugs would be needed to achieve satisfactory analgesia. |
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