| 管艳芹,刘建群,吴秀芳.卵巢癌组织中EZH2蛋白表达与临床病理特征及预后的关系[J].肿瘤学杂志,2015,21(11):875-879. |
| 卵巢癌组织中EZH2蛋白表达与临床病理特征及预后的关系 |
| The Relationship of Expression of EZH2 Protein with Clinicopathological Characteristics and Prognosis in Ovarian Carcinoma |
| 投稿时间：2015-03-01 |
| DOI：10.11735/j.issn.1671-170X.2015.11.B003 |
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| 中文关键词: 卵巢肿瘤 果蝇zeste 基因增强子同源物2 细胞周期蛋白D1 基质金属蛋白酶-9 肿瘤转移 |
| 英文关键词:ovarian neoplasms enhancer of zeste homolog 2 Cyclin D1 matrix metalloproteinase-9( MMP-9) neoplasm metastasis |
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| 摘要点击次数: 2055 |
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| 中文摘要: |
| 摘 要：［目的］ 检测果蝇zeste基因增强子同源物2（EZH2）、细胞周期蛋白D1(Cyclin D1)及基质金属蛋白酶-9(MMP-9)在卵巢癌组织中表达情况及与临床病理特征预后的关系，分析EZH2检测的临床意义。［方法］ 采用免疫组织化学法(SP法)检测85例卵巢癌、30例卵巢良性肿瘤、30例正常卵巢组织中EZH2、Cyclin D1及MMP-9蛋白表达情况。［结果］ EZH2蛋白在卵巢癌组织中的阳性表达率为72.9%（62/85），较卵巢良性肿瘤组20.0%（6/30）和对照组10.0%（3/30）显著增高（P<0.05）；Cyclin D1蛋白在卵巢癌组织中的阳性表达率为60.0%（51/85），较卵巢良性肿瘤组13.3%（4/30）和对照组10.0%（3/30）显著增高（P<0.05）；MMP-9蛋白在卵巢癌组织中的阳性表达率为90.6%（77/85），较卵巢良性肿瘤组23.3%（7/30）和对照组6.7%（2/30）显著增高（P<0.05）。EZH2、Cyclin D1及MMP-9蛋白表达与卵巢癌分化程度、FIGO临床分期、淋巴结转移、脉管瘤栓有明显相关性(P<0.05)。Kaplan-Meier生存分析表明，卵巢癌EZH2蛋白表达阳性患者的生存期短于阴性表达者(P<0.05)，经相关性分析发现，EZH2与Cyclin D1及MMP-9蛋白表达呈正相关(r=0.314，0.298；均P<0.01)。［结论］ EZH2参与卵巢癌的发生发展，可能与Cyclin D1、MMP-9协同促进卵巢癌的恶性增殖与转移，是卵巢癌预后的危险因素。 |
| 英文摘要: |
| Abstract：［Purpose］ To investigate the expressions of enhancer of zeste homolog 2(EZH2)，Cyclin D1 and matrix metalloproteinase-9(MMP-9) in ovarian carcinoma as well as the relationship of expression of EZH2 with clinicopathological characteristics and prognosis in ovarian carcinoma，and to analyze the clinical significance of detection of EZH2. ［Methods］ EZH2，Cyclin D1 and MMP-9 proteins were detected in 85 cases with ovarian carcinoma and 30 cases with benign tumors and 30 samples of normal ovarian tissues by immunohistochemical staining method(SP). ［Results］ In ovarian carcinoma，the positive expression rate of EZH2 was 72.9%(62/85)，which was significantly higher than that in benign tumors (20.0%，6/30) and control group (10.0%，3/30) (P<0.05). In ovarian carcinoma，the positive expression rate of Cyclin D1 was 60.0%(51/85)，which was significantly higher than that in benign tumors(13.3%，4/30) and control group (10.0%，3/30)(P<0.05). In ovarian carcinoma，the positive expression rate of MMP-9 was 90.6%(77/85)，which was higher than that in benign tumors (23.3%，7/30) and control group(6.7%，2/30)(P<0.05). The expressions of these three proteins were significantly correlated with the tumor differentiation grade，clinical stage，lymph node metastasis and vascular embolus(P<0.05). Kaplan-Meier analysis indicated that the overall survival rate was lower in patients with a positive expression of EZH2 than those with negative expression(P<0.05) .In ovarian carcinoma，EZH2 expression was positively correlated with Cyclin D1 and MMP-9 (r=0.314，0.298；both with P<0.01). ［Conclusion］ EZH2 expression might involve in the development of ovarian carcinoma and promote the proliferation and metastasis of ovarian carcinoma by interacting with Cyclin D1 and MMP-9，and overexpression of EZH2 might be as a prognostic risk factor of ovarian carcinoma. |
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