| 胡晓莉,王建红,李春笋.Her-2/neu与术后复发晚期胃癌临床病理及预后的相关性研究[J].肿瘤学杂志,2015,21(9):730-733. |
| Her-2/neu与术后复发晚期胃癌临床病理及预后的相关性研究 |
| The Correlation of Her-2/neu Expression with Clinicopathologic Features and Prognosis in Postoperative Recurrent Gastric Cancer |
| 投稿时间：2014-05-24 |
| DOI：10.11735/j.issn.1671-170X.2015.09.B006 |
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| 中文关键词: 胃肿瘤 Her-2/neu 预后 临床病理学 |
| 英文关键词:gastric neoplasms Her-2/neu prognosis clinicopathology |
| 基金项目:南通市科学技术局项目（S10910，W201009） |
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| 中文摘要: |
| 摘 要：［目的］ 探讨术后复发晚期胃癌患者Her-2/neu表达及与临床病理特征和预后的相关性。［方法］ 分别采用免疫组织化学法（IHC）及荧光原位杂交法（FISH）对108例术后复发晚期胃癌患者进行Her-2/neu表达的检测，分析其与患者的年龄、性别、Lauren分型、组织学分级及与预后的相关性。［结果］ 108例患者中，IHC法检测Her-2/neu阳性表达13例，FISH法检测Her-2/neu阳性表达14例，两种方法均为阳性表达者10例，一致率为61.5 %。15例正常胃黏膜中未见阳性表达。Her-2/neu表达与患者的年龄、性别、肿瘤部位、组织学分级、TNM分期、浸润深度、有无脉管浸润无关（P＞0.05），而与患者的Lauren分型、淋巴结转移有关（P＜0.05）。Her-2/neu阳性患者的中位疾病进展时间（TTP）为22.4个月（95%CI：23.44~26.55），阴性患者的中位TTP为25.0个月（95%CI：17.02~27.77），两者差异无统计学意义(P=0.215)。［结论］ Her-2/neu可能是胃癌预后不良的标志之一。 |
| 英文摘要: |
| Abstract：［Purpose］ To investigate the correlation of Her-2/neu expression with clinicopathologic features and prognosis in postoperative recurrent gastric cancer. ［Methods］ Her-2/neu expression was detected in 108 cases of advanced gastric cancer with recurrence postoperation by immunohistochemical method (IHC) and fluorescence in situ hybridization (FISH)，and the correlation of Her-2/neu with age，gender，Lauren type，histological grade，prognosis was analyzed.［Results］ Of 108 patients，there were 13 cases with positive expression of Her-2/neu by IHC，14 cases with positive expression of Her-2/neu by FISH method. There were 10 cases with positive expression of Her-2/neu in both IHC and FISH，with consistent rate of 61.5%. No expression of Her-2/neu was found in 15 cases of normal gastric mucosa. No significant correlation was found between Her-2/neu expression and the patient’s age，gender，tumor location，histological grade，TNM stage，depth of invasion，and vascular invasion（P＞0.05）. There was significantly positive correlation between Her-2/neu expression and Lauren classification， lymph node metastasis（P＜0.05）. Median time to progression (TTP) was 22.4 months in Her-2/neu positive patients（95%CI：23.44～26.55 ），and 25.0 months（95%CI：17.02～27.77）in negative patients，without significant difference between them(P=0.215). ［Conclusion］ Her-2/neu might be a predictive indicator for poor prognosis in patients with recurrent gastric cancer. |
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