| 刘金菊,王秀问,张灵智.晚期胃癌患者化疗前血清VEGF和内皮抑素水平及其临床意义[J].肿瘤学杂志,2015,21(9):721-724. |
| 晚期胃癌患者化疗前血清VEGF和内皮抑素水平及其临床意义 |
| The Levels of Serum Vascular Endothelial Growth Factor and Endostatin in Patients with Advanced Gastric Cancer Before Chemotherapy and Their Clinical Significance |
| 投稿时间：2014-06-19 |
| DOI：10.11735/j.issn.1671-170X.2015.09.B004 |
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| 中文关键词: 胃肿瘤 血管内皮生长因子 内皮抑素 |
| 英文关键词:gastric neoplasms vascular endothelial growth factor(VEGF) endostatin |
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| 中文摘要: |
| 摘 要：［目的］ 探讨晚期胃癌患者化疗前血清血管内皮生长因子(vascular endothelial growth factor，VEGF)和内皮抑素(endostatin)的水平及其临床意义。［方法］ ELISA法检测38例晚期胃癌患者化疗前血清VEGF和endostatin的水平，并以慢性胃炎患者和健康人群作对照。［结果］ 晚期胃癌患者化疗前血清VEGF和endostatin水平显著高于慢性胃炎患者和健康人群（P均<0.01）。VEGF水平高的胃癌患者其endostatin水平也相应升高，两者呈正相关（r=0.7549，P<0.01），且两者水平与患者年龄、性别无明显相关（P均>0.05），而与病理类型、细胞分化程度及患者预后相关（P均<0.05）。［结论］ VEGF和endostatin参与了肿瘤血管的生成，与胃癌的临床病理生理相关，对评价患者预后有一定的参考价值。 |
| 英文摘要: |
| Abstract：［Purpose］ To investigate the levels of serum vascular endothelial growth factor(VEGF) and endostatin in patients with advanced gastric cancer before chemotherapy and their clinical significance.［Methods］ Serum VEGF and endostatin in 38 cases with advanced gastric cancer before chemotherapy were detected by enzyme-linked immunosorbent assay(ELISA). The cases with chronic gastritis and healthy persons were as controls.［Results］ The serum levels of VEGF and endostatin in patients with advanced gastric carcinoma before chemotherapy were significantly higher than those in patients with chronic gastritis and healthy controls(P<0.01). There was a significant positive correlation between serum VEGF and endostatin levels，and the correlation coefficient was 0.7549(P<0.01). The serum levels of VEGF and endostatin were not related to patients’ age，gender(P>0.05)，but were closely related to pathological type，grade and prognosis of the patients (P<0.05). ［Conclusion］ VEGF and endostatin involve in the angiogenesis of tumor，correlate with clinical pathophysiology and have certain reference value for the prognosis evaluation in patients with gastric cancer. |
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