| 杨会生,王 韩,汤宛莹.联合检测CA724、CA199、CEA对胃癌诊断价值的Meta分析[J].肿瘤学杂志,2015,21(9):714-720. |
| 联合检测CA724、CA199、CEA对胃癌诊断价值的Meta分析 |
| Combined Detection of CA724，CA199 and CEA in the Diagnosis for Gastric Cancer：A Meta Analysis |
| 投稿时间：2014-10-31 |
| DOI：10.11735/j.issn.1671-170X.2015.09.B003 |
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| 中文关键词: CA724 CA199 CEA 胃肿瘤 Meta分析 诊断 |
| 英文关键词:CA724 CA199 CEA gastric neoplasms Meta analysis diagnosis |
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| 中文摘要: |
| 摘 要：［目的］ 系统评价联合检测血清肿瘤标志物（CA724、CA199、CEA）对胃癌的诊断价值。［方法］ 计算机检索PubMed、中国知网、万方、维普等数据库，收集关于CA724、CA199、CEA在胃癌诊断中应用的相关文献。采用Meta-Disc l.4、RevMan 5.2和Stata 13.0进行Meta分析。［结果］ 纳入10篇文献，共1642例。对胃癌诊断中，单独检测CA724的敏感度为0.49(95%CI：0.45~0.53)，特异度为0.91(95%CI：0.89~0.93)，诊断比值比为10.97(95%CI：8.22~14.63)；联合检测的敏感度为0.76(95%CI：0.73~0.79)，特异度为0.82(95%CI：0.79~0.84)，诊断比值比为19.85(95%CI：10.78~36.52)。单独检测CA724的曲线下面积（AUC）=0.80，Q*=0.74；联合检测的AUC=0.95，Q*=0.90。联合检测和单独检测CA724两种方式的诊断效能差异具有统计学意义（Z=4.86，P＜0.05）。［结论］ CA724联合检测的诊断效能比单独检测CA724要高，对胃癌的辅助诊断具有较高的指导意义。 |
| 英文摘要: |
| Abstract：［Purpose］ To systematically evaluate the value of combined detection of serum CA724，CA199 and CEA in the diagnosis of gastric cancer.［Methods］ Related literatures about the diagnosis of gastric cancer were retrieved from PubMed，CNKI，WanFang，VIP and other databases on the computer，and Meta-analysis was performed by Meta-Disc l.4，RevMana 5.2 and Stata 13.0.［Results］ Ten studies were recruited，which included 1642 cases. In the diagnosis of gastric cancer，the sensitivity(SEN)，specificity(SPE) and diagnostic odds ratio(DOR) of detection of CA724 alone were 0.49(95%CI：0.45～0.53)，0.91(95%CI：0.89～0.93)，and 10.97(95%CI：8.22～14.63) respectively，and those for combined detection of serum CA724，CA199 and CEA were 0.76(95%CI：0.73～0.79)，0.82(95% CI：0.79～0.84)，and 19.85(95%CI：10.78～10.78) respectively. AUC and Q* of detection of CA724 alone were 0.80 and 0.74 respectively，and those for combined detection of serum CA724，CA199 and CEA were 0.95 and 0.90 respectively. There was significant difference of diagnostic efficiency between the two methods（Z=4.86，P＜0.05）. ［Conclusion］ The combined detection of CA724，CA199 and CEA has higher diagnostic efficiency for gastric cancer than detection of CA724 alone，which might have high guiding significance for the clinical diagnosis of gastric cancer. |
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