| 郑 真,谢聪颖.胃癌的Lauren分型与个体化治疗[J].肿瘤学杂志,2015,21(8):688-693. |
| 胃癌的Lauren分型与个体化治疗 |
| Review on Lauren Classification and Individual Treatments of Gastric Cancer |
| 投稿时间：2014-12-03 |
| DOI：10.11735/j.issn.1671-170X.2015.08.B014 |
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| 中文关键词: 胃肿瘤 Lauren分型 化学药物治疗 个体化治疗 |
| 英文关键词:gastric neoplasms Lauren classification chemotherapy individual treatment |
| 基金项目: |
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| 中文摘要: |
| 摘 要：胃癌在全世界和我国均是最常见的恶性肿瘤之一，虽然目前临床诊疗技术不断提高，但大部分胃癌在确诊时偏晚期，并且部分患者早期手术根治后仍可能发生复发和转移。新药及新的临床研究不断应用于临床，但晚期患者总体疗效仍然欠佳，个体差异较大。Lauren分型将胃癌分为肠型、弥漫型和混合型，不同的病理类型有不同的肿瘤生物学行为，其预后差异较大。因而能否根据胃癌的分型对放化疗方案进行优化，指导临床进行个体化治疗，成为目前亟待解决的问题。本文就胃癌不同Lauren分型对不同化疗药物及放疗的疗效区别进行综述，以更好地指导临床的个体化治疗。 |
| 英文摘要: |
| Abstract：Gastric cancer is one of the most common malignant tumors in the world，including China. Although current clinical diagnosis and treatment has been improved greatly，most definite diagnosis of gastric cancer has reached advanced stage，and some of the patients may have the possibility of recurrence and metastasis after early operation. New drugs and new clinical studies have been continuously used in clinic，however，the general efficacy of the patients with advanced stages is not so good，and the individual differences are quite large. Lauren classification has classified gastric cancer into three kinds：the intestinal type gastric cancer，the diffuse type gastric cancer and the mixed type gastric cancer. According to different pathological types，there are different tumor biological behaviors and the differences of prognosis are quite large. As a result，how to optimize the chemotherapy scheme，and guide individual clinical treatment，based on the classification of gastric cancer is still one of the most sophisticated problems needed to be solved urgently. This paper reviews the differences of the curative effects of Lauren classification on different kinds of chemotherapeutic drugs and radiotherapy，and hope to have efficient effect on guiding individual clinical treatment. |
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