| 中文关键词: 胃肿瘤 侵袭 上皮间质转化 miR-210 |
| 英文关键词:gastric neoplasms invasion epithelial mesenchymal transition miR-210 |
| 基金项目:浙江省自然科学基金（LY14H160007） |
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| 中文摘要: |
| 摘 要：胃癌是消化道最常见的恶性肿瘤之一，发病率和死亡率均较高，复发和转移是导致胃癌治疗效果差的主要原因。miR-210是近年研究较为活跃的细胞调控因子，在胃癌的发生、发展尤其是侵袭转移方面发挥了重要作用。研究表明，miR-210可通过多种途径诱导胃癌细胞发生上皮间质转化，导致胃癌复发和转移。本文就miR-210在胃癌中的研究进展作一综述。 |
| 英文摘要: |
| Abstract：Gastric cancer is one of the most common malignant tumors，with high incidence and mortality rates. Recurrence and metastasis are the main causes of the poor therapeutic effect of gastric cancer. A cell regulatory factor miR-210 has become a hot spot in recent years，which plays an important role in development，invasion and metastasis of gastric cancer. Recent researches have shown that miR-210 can induce epithelial mesenchymal transition(EMT) through a variety of passways，which lead to the recurrence and metastasis of gastric cancer. This paper reviews the study progression of miR-210 in gastric cancer. |
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