| 陈震章,朱向帜,周益琴.食管癌外照射放疗后腔内后装加量的临床分析[J].肿瘤学杂志,2015,21(8):663-665. |
| 食管癌外照射放疗后腔内后装加量的临床分析 |
| Clinical Study of Intracavitary Brachytherapy Boost Following External Irradiation for Esophageal Cancer |
| 投稿时间：2014-12-11 |
| DOI：10.11735/j.issn.1671-170X.2015.08.B008 |
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| 中文关键词: 食管肿瘤 放射治疗 近距离放疗 |
| 英文关键词:esophageal neoplasms radiotherapy brachytherapy |
| 基金项目: |
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| 摘要点击次数: 2723 |
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| 中文摘要: |
| 摘 要：［目的］评价食管癌外照射放疗后腔内后装加量治疗的不良反应，并分析其治疗疗效。［方法］回顾性分析初诊食管鳞癌患者27例，外照射放疗1～2周后采用192铱腔内后装加量，外照射放疗剂量50～67Gy/25～33f，腔内后装放疗剂量4～10Gy/1～2f，其中16例患者联合化疗。［结果］全组患者近期疗效评价有效率100%，其中CR 15例（55.6%），PR 12例（44.4%）。Ⅲ级以上放射性食管炎和血液学毒性分别为1例（3.7%）和6例（22.2%），无食管穿孔及大出血发生。随访中位时间为35个月，至随访截止时食管局部复发4例，死亡6例，2年局部控制率为84.7%，2年和3年生存率分别为88.9%和78.9%。［结论］食管癌外照射放疗后腔内后装加量治疗可耐受，并能获得较好的治疗疗效。 |
| 英文摘要: |
| Abstract：［Purpose］To investigate the toxicity and efficacy of intracavitary brachytherapy boost following external irradiation for esophageal cancer. ［Methods］ Twenty-seven patients with esophageal cancer were retrospectively reviewed. All patients received radiotherapy consisting of external irradiation to a total dose of 50~67Gy in 25~33 fractions，followed by brachytherapy to 4~10Gy in 1~2 fractions. Sixteen cases also received chemotherapy. ［Results］ The complete response and partial response rate were 55.6% and 44.4%，respectively. Grade 3 or higher than acute toxicities occurred in 7 cases，including esophagitis(1 case) and hematologic toxicities (6 cases). No acute esophageal bleeding and fistula occurred during treatment period. The median follow-up time was 35 months. Up to the deadline of follow-up，there were 4 cases of local recurrence and 6 cases died. The 2-year local control rate was 84.7%. The overall survival rate at 2 and 3 years were 88.9% and 78.9%，respectively．［Conclusion］ Combined external irradiation and brachytherapy boost for esophageal cancer is tolerable，and can produce favorable local control and survival rates. |
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