| 严 赟,杨博洋,吴伟主.乳腺癌患者色素上皮衍生因子表达及其与超声征象的相关性分析[J].肿瘤学杂志,2015,21(7):587-590. |
| 乳腺癌患者色素上皮衍生因子表达及其与超声征象的相关性分析 |
| Expression of Pigment Epithelium-derived Factor (PEDF） and Its Correlation with Ultrasound Features in Breast Cancer Patients |
| 投稿时间：2014-07-23 |
| DOI：10.11735/j.issn.1671-170X.2015.07.B012 |
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| 中文关键词: 乳腺肿瘤 色素上皮衍生因子 超声检查 |
| 英文关键词:breast neoplasms pigment epithelium-derived factor ultrasound |
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| 中文摘要: |
| 摘 要：［目的］ 分析乳腺癌患者色素上皮衍生因子（PEDF）表达及其与超声征象的相关性。［方法］ 以208例乳腺癌患者为研究对象，记录肿块的超声征象，探测肿块血流情况，用免疫组化方法测得所有石蜡组织标本中PEDF蛋白的表达情况，分析不同血流分级组和不同超声征象组PEDF表达阳性率的差异。［结果］ 导管上皮增生性疾病中PEDF蛋白阳性表达率（55.00%）显著高于乳腺癌患者（29.81%），差异有统计学意义（P＜0.01）。浸润性导管癌、浸润性小叶癌、黏液癌+浸润性筛状癌PEDF蛋白阳性表达率分别为26.86%、47.37%和57.14%，3组间比较，差异有统计学意义（P＜0.05）。彩色多普勒血流分级0级、Ⅰ级、Ⅱ级、Ⅲ级PEDF蛋白表达阳性率分别为46.88%、31.82%、31.48%、13.95%，各组间比较，差异有统计学意义（P＜0.05）。肿瘤直径≤2cm的病灶中PEDF蛋白表达阳性率（44.63%）显著高于肿瘤直径＞2cm者（14.94%），差异有统计学意义（P＜0.05）。［结论］ PEDF在乳腺癌患者中表达明显下降，浸润性导管癌患者PEDF表达阳性率最低，PEDF表达与超声可见的宏观影像表现具有相关性。 |
| 英文摘要: |
| Abstract：［Purpose］ To investigate the expression of pigment epithelium-derived factor(PEDF）and its correlation with ultrasound features in breast cancer patients.［Methods］ Two hundred and eight breast cancer patients were enrolled，and the ultrasound features and blood flow were recorded，and the expression of PEDF was analyzed immunohistochemically. The positive expression rate of PEDF was compared in the patients with different blood flow classifications and different ultrasound features. ［Results］ The positive expression rate of PEDF in ductal epithelial hyperplasia disease group was significantly higher than that in breast cancer group（55.00% vs 29.81%,P＜0.01）. There was significant difference of positive expression rates of PEDF among patients with invasive ductal carcinoma，invasive lobular carcinoma，mucinous carcinoma and invasive cribriform carcinoma(26.86%,47.37% and 57.14%,P＜0.05）. There was significant difference of the positive expression rates of PEDF in patients with different color Doppler blood flow classifications (0~Ⅲ：46.88%,31.82%,31.48% and 13.95% respectively，P＜0.05）. The positive expression rate of PEDF in patients with tumor diameter ≤ 2cm was significantly higher than that in patients with tumor diameter ＞2cm（44.63% vs 14.94%,P＜0.05）. ［Conclusion］ The expression of PEDF in breast cancer patients is obvious decreased，and the infiltrating ductal carcinoma patients are the lowest expression level. The expression of PEDF is correlated with the macroscopic ultrasonic image. |
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