| 王文娴,郑 蕾,宋正波.101例难治性小细胞肺癌的二线治疗生存分析[J].肿瘤学杂志,2015,21(7):546-550. |
| 101例难治性小细胞肺癌的二线治疗生存分析 |
| Analysis of Survival of 101 Cases with Refractory Recurrent Small Cell Lung Cancer with Second-line Treatment |
| 投稿时间：2014-09-27 |
| DOI：10.11735/j.issn.1671-170X.2015.07.B003 |
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| 中文关键词: 癌，小细胞 肿瘤复发 二线治疗 生存期 肺肿瘤 |
| 英文关键词:carcinoma,small cell neoplasm recurrence second-line chemotherapy survival lung neoplsms |
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| 中文摘要: |
| 摘 要：［目的］探讨含铂双药化疗和单药化疗用于难治复发小细胞肺癌（small cell lung cancer，SCLC）患者二线化疗的疗效及安全性。［方法］ 回顾性分析101例难治性SCLC患者二线治疗的疗效和生存情况，并采用Cox多因素分析模型进行预后相关因素的分析。［结果］单药和双药组有效率(response rate，RR) 分别为2.9%和7.5%(P=0.208)，疾病控制率 (disease control rate，DCR) 分别为14.7%和59.7%(P<0.001)，中位无进展生存期(progression-free survival，PFS)分别为1.23个月和2.77个月(P<0.001)。两组中位总生存期(overall survival，OS)差异无统计学意义(5.40个月vs 5.93个月，P=0.988)。Ⅲ~Ⅳ度不良反应单药组比双药组发生率低(20.6% vs 52.2%，P=0.007)。多因素分析显示体能状况评分(performance status，PS)（HR=1.491，P=0.002）是PFS的独立影响因素。［结论］双药治疗可延长部分患者的PFS，但不良反应相对增加。 |
| 英文摘要: |
| Abstract：［Purpose］ To investigate the efficacy and safety of two-agent chemotherapy (combination chemotherapy) and single-agent chemotherapy(single chemotherapy) based on platinum as second-line chemotherapy in patients with refractory recurrent small cell lung cancer (SCLC).［Methods］ The efficacy and survival of 101 cases with refractory recurrent SCLC treated with second-line chemotherapy were analyzed，and prognostic factors were analyzed by COX proportional hazards model.［Results］ In single chemotherapy and combination chemotherapy groups，the response rate (RR) were 2.9% and 7.5% respectively(P=0.208)；disease control rate，14.7% and 59.7%(P<0.001)；median progression-free survival (PFS)，1.23 and 2.77 months (P<0.001)，with significant difference. And there was no significant difference in median overall survival (OS) in the two groups( 5.40 and 5.93 months，P=0.988).The rate of toxicities grade Ⅲ~Ⅳ in single chemotherapy group was lower than that in combination chemotherapy group (20.6% vs 52.2%，P=0.007).The COX proportional hazards model analysis revealed that performance status score before second-line chemotherapy(0-1 vs 2；hazard ration=1.491，P=0.002) was an independent prognostic predictor of PFS after second-line chemotherapy.［Conclusion］ Two-agent chemotherapy as a second-line chemotherapy regimen has an advantage of prolonging PFS，but increases toxicities. |
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