盖 领,茅国新,沈 浮.IGF-1R在非小细胞肺癌中的表达及其临床意义[J].肿瘤学杂志,2015,21(7):542-545. |
IGF-1R在非小细胞肺癌中的表达及其临床意义 |
IGF-1R Expression in Non-small Cell Lung Cancer and Its Clinical Significance |
投稿时间:2015-05-14 |
DOI:10.11735/j.issn.1671-170X.2015.07.B002 |
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中文关键词: 非小细胞肺癌(NSCLC) 胰岛素样生长因子-1受体(IGF-1R) 预后 |
英文关键词:non-small cell lung cancer IGF-1R prognosis |
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中文摘要: |
摘 要:[目的] 探讨IGF-1R在非小细胞肺癌(non-small cell lung cancer,NSCLC)中的表达及其临床意义。[方法] 用免疫组织化学染色检测IGF-1R在147例NSCLC组织和40例癌旁组织中的表达,并分析其表达与临床病理特征及预后之间的关系。[结果] IGF-1R在NSCLC组织中的阳性表达率为48.3%(71/147),高于癌旁肺组织中的表达(7.5%,3/40),两者差异有统计学意义(P<0.05)。IGF-1R的阳性表达与肿瘤大小、临床分期及淋巴结转移有关(P<0.05);而与患者年龄、性别、吸烟、组织学类型和组织学分级均无关。经Kaplan-Meier生存分析,IGF-1R阳性表达者比阴性表达者生存期短(P<0.05)。多因素COX比例风险模型分析显示,淋巴结转移状态(P<0.05)是影响NSCLC预后的独立危险因素。[结论] IGF-1R异常表达可能与NSCLC的发生发展和预后关系密切,有望成为评估NSCLC预后的有效指标。 |
英文摘要: |
Abstract:[Purpose]To investigate the expression of IGF-1R in non-small cell lung cancer (NSCLC) and its clinical significance. [Methods] The immunohistochemical method was used to detect the expression of IGF-1R in 147 cases of NSCLC tissues and 40 cases of cancer adjacent tissues,and its relationship with clinicopathological features and prognosis was analyzed. [Results] The positive expression rate of IGF-1R in NSCLC was 48.3%(71/147),which was higher than that in adjacent tissues(7.5%,3/40),with significant difference between them(P<0.05). The positive expression of IGF-1R was related to tumor size,clinical stage and lymph node metastasis(P<0.05),but not related to age,gender,smoking,histological type and histological grade. The results of Kaplan-Meier survival analysis indicated that positive expression of IGF-1R was associated with worse survival(P<0.05). COX’s proportional hazards model showed that lymph node metastasis was an independent risk factor for prognosis of NSCLC patients. [Conclusion]The abnormal expression of IGF-1R might be closely related to the initiation,development and progression of NSCLC. It was probable to evaluate the prognosis of NSCLC with expression of IGF-1R. |
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