| 谢颂平,康敢军,江文洋.CXCR4的表达与肺腺癌顺铂耐药的临床研究[J].肿瘤学杂志,2015,21(7):539-541. |
| CXCR4的表达与肺腺癌顺铂耐药的临床研究 |
| Expression of CXCR4 and Cisplatin-resistance in Lung Adenocarcinoma |
| 投稿时间：2014-11-03 |
| DOI：10.11735/j.issn.1671-170X.2015.07.B001 |
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| 中文关键词: 肺肿瘤 腺癌 CXCR4 顺铂 耐药 |
| 英文关键词:lung neoplasms adenocarcinoma CXCR4 cisplatin drug resistance |
| 基金项目:湖北省自然科学基金资助项目（2014CFA070） |
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| 中文摘要: |
| 摘 要：［目的］ 分析CXCR4在肺腺癌中的表达及其与铂类耐药的关系。［方法］ 采用免疫组化SP法检测CXCR4在71例ⅢA期肺腺癌中的表达，分析其表达与肺腺癌顺铂耐药及预后的关系。［结果］ CXCR4在71例ⅢA期肺腺癌中的阳性表达率为85.9%。耐药组肺癌患者与敏感组相比，CXCR4表达升高，且预后差，两组比较差异有统计学意义(P<0．05)。［结论］CXCR4蛋白阳性表达与ⅢA期肺腺癌顺铂耐药有关。 |
| 英文摘要: |
| Abstract：［Purpose］ To investigate the relationship of CXCR4 expression with cisplatin resistance in lung adenocarcinoma．［Methods］ Expression of CXCR4 in 71 specimens of lung adenocarcinoma stage ⅢA was detected immunohistochemically． The relationship of CXCR4 expression with cisplatin resistance and prognosis were analyzed．［Results］ The positive rate of CXCR4 in lung adenocarcinoma was 85.9%(61/71).Patients in cisplatin-resistant group had higher expression rate of CXCR4 and worse prognosis compared with patients in cisplatin-sensitive group (P<0.05)．［Conclusion］ An elevated expression of CXCR4 is correlated with cisplatin resistance in lung adenocarcinoma patients. |
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