| 中文关键词: 肿瘤血管生成 血管生成拟态 肿瘤微血管构筑表型异质性 |
| 英文关键词:tumor angiogenesis vasculogenic mimicry(VM) tumor microvascular architecture phenotype heterogeneity (T-MAPH) |
| 基金项目:国家自然科学基金面上项目（81272378） |
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| 中文摘要: |
| 摘 要：恶性肿瘤的快速生长、转移与血管密切相关。大量研究表明，肿瘤血管生成细胞的来源存在多源性，血管生成的过程呈多样性，血管生成的调节呈多靶点性。这些特征提示研究者需拓宽思路，从不同层面理解肿瘤的新生血管生成机制，进而为寻找高度选择性血管靶点的临床抗肿瘤药物提供新的思路。 |
| 英文摘要: |
| Abstract：Tumor angiogenesis contributes to tumor growth and metastasis. A number of studies indicate that tumor angiogenesis is a very complex process，in which multiple cellular origin and vasculogenic mimicry are involved. The vessels in tumor tissue，comparing to the normal ones，are heterogeneity in both of the structure and bio-characteristics. More and more targets on blood vessels have been discovered. The complexity of tumor angiogenesis may provide new insight into developing new targeted therapies of cancer. |
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