| 杨 俊,程怀东,王年飞.脑转移瘤全脑放疗后前瞻性记忆与回顾性记忆功能损害的研究[J].肿瘤学杂志,2015,21(6):482-486. |
| 脑转移瘤全脑放疗后前瞻性记忆与回顾性记忆功能损害的研究 |
| Study of Prospective and Retrospective Memory Impairment in Patients with Brain Metastases After Whole Brain Radiotherapy |
| 投稿时间：2014-08-01 |
| DOI：10.11735/j.issn.1671-170X.2015.06.B008 |
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| 中文关键词: 转移瘤 放射治疗 前瞻性记忆 回顾性记忆 |
| 英文关键词:brain metastases radiotherapy prospective memory retrospective memory |
| 基金项目:国家自然科学基金资助项目（81372487） |
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| 中文摘要: |
| 摘 要：［目的］ 了解脑转移瘤患者全脑放疗后前瞻性记忆（PM）与回顾性记忆（RM）的功能损害情况。［方法］ 以34例脑转移瘤患者为研究对象，在全脑放疗前1周、放疗后1个月分别进行简易精神状态量表（MMSE）测查及RM和PM问卷调查。［结果］ 放疗前后MMSE评分（27.26±1.86 vs 26.35±1.76）差异具有统计学意义（P<0.05）。放疗后PM成绩为12.18±2.74，低于放疗前（14.06±4.66）（P<0.01）；RM成绩放疗前后（14.26±4.60 vs 14.18±4.41）差异无统计学意义（P>0.05）。［结论］ 全脑放疗对脑转移瘤患者的总体认知功能有损害，但可改善患者PM功能，RM功能无明显影响。 |
| 英文摘要: |
| Abstract：［Purpose］ To investigate the prospective memory(PM) and retrospective memory (RM) impairment in patients with brain metastases after whole brain radiotherapy.［Methods］ Thirty?鄄four patients with brain metastases were enrolled in this study. MMSE and questionnaires of RM and PM were conducted one week before and one month after whole brain radiotherapy.［Results］ MMSE scores before and after radiotherapy were statistically different［(27.26±1.86) vs (26.35±1.76)，P<0.05］. Compared with patients before radiotherapy，patients after radiotherapy had lower PM score［(12.18±2.74) vs(14.06±4.66)，P<0.01］，also had lower RM score，but with no significance［(14.26±4.60) vs (14.18±4.41)，P>0.05］. ［Conclusion］ Whole brain radiotherapy has damage on general cognition in patients with brain metastases，while it may contribute to prospective memory improvement and it has no significant impact on retrospective memory. |
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