| 陈小悦,张金库,陈 雪.基底细胞样型乳腺癌中Cdc42 和IQGAP1的表达及临床意义[J].肿瘤学杂志,2015,21(5):387-391. |
| 基底细胞样型乳腺癌中Cdc42 和IQGAP1的表达及临床意义 |
| Expressions of IQGAP1 and Cdc42 in Basal-Like Breast Cancer and Their Clinical Significance |
| 投稿时间：2014-10-28 |
| DOI：10.11735/j.issn.1671-170X.2015.05.B008 |
|
 |
| 中文关键词: 乳腺肿瘤 基底细胞样型 细胞分裂周期蛋白42（Cdc42） 支架蛋白1（IQGAP1） |
| 英文关键词:breast neoplasms basal-like Cdc42 IQGAP1 |
| 基金项目: |
|
| 摘要点击次数: 1711 |
| 全文下载次数: 715 |
| 中文摘要: |
| 摘 要：［目的］ 分析细胞分裂周期蛋白42（Cdc42）和支架蛋白1（IQGAP1）与基底细胞样型乳腺癌（basal-like breast cancer，BLBC）临床病理特征之间的关系及二者之间的相关性，探讨Cdc42和IQGAP1在BLBC发生、发展及侵袭转移中的作用。［方法］ 采用免疫组化方法检测60例BLBC、45例非基底细胞样型乳腺癌（non-basal-like breast carcinoma ，Non-BLBC）和35例癌旁正常乳腺组织中Cdc42和IQGAP1的表达。［结果］ Cdc42在BLBC中的表达明显高于Non-BLBC和癌旁正常乳腺组织（P＜0.0125），IQGAP1在BLBC和Non-BLBC中的表达明显高于癌旁正常乳腺组织（P＜0.0125）；BLBC中Cdc42的表达与淋巴结转移和TNM分期密切相关（P＜0.05），IQGAP1的表达与肿瘤大小和淋巴结转移密切相关（P＜0.05），并且两者在BLBC中的表达呈正相关关系（r＝0.638，P＜0.05）。［结论］ Cdc42和IQGAP1可能是促进肿瘤的局部侵袭和远处转移的重要因素，在BLBC的发生发展中起着重要的作用。 |
| 英文摘要: |
| Abstract：［Purpose］ To investigate the relationship of Cdc42 and IQGAP1 with the clinicopathologic features of basal-like breast cancer(BLBC) and the role of Cdc42 and IQGAP1 in the carcinogenesis，invasion and metastasis of BLBC. ［Methods］ The expressions of Cdc42 and IQGAP1 in 60 cases with BLBC，45 cases with non-basal-like breast cancer (Non-BLBC) and 35 cases of cancer adjacent tissues were detected immunohistochemically. ［Results］ The expression of Cdc42 in BLBC were significantly higher than that in Non-BLBC and cancer adjacent tissues（P＜0.0125），the expressions of IQGAP1 in BLBC and Non-BLBC were significantly higher than that in cancer adjacent tissues(P<0.0125).The expression of Cdc42 positively correlated with lymph nodes metastasis and TNM staging of BLBC(P<0.05)，the expression of IQGAP1 positively correlated with tumor size and lymph nodes metastasis of BLBC(P<0.05)，and there was positive correlation between the expressions of Cdc42 and IQGAP1 in BLBC(r=0.638，P<0.05) ［Conclusion］ Cdc42 and IQGAP1 may be important factors in tumor invasion and distant metastasis，and play important roles in the carcinogenesis of BLBC. |
|
在线阅读
查看全文 查看/发表评论 下载PDF阅读器 |