| 王 冬,李 勇,赵 群.莪术油注射液在胃癌患者围手术期应用的临床意义[J].肿瘤学杂志,2015,21(5):378-381. |
| 莪术油注射液在胃癌患者围手术期应用的临床意义 |
| Clinical Significance of Zcdoary Turmeric Oil Injection in Application for Perioperative Patients with Gastric Cancer |
| 投稿时间：2015-03-04 |
| DOI：10.11735/j.issn.1671-170X.2015.05.B006 |
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| 中文关键词: 胃肿瘤 莪术油注射液 围手术期 流式细胞术 炎症反应 |
| 英文关键词:gastric neoplasms Zcdoary Turmeric oil injection perioperative period flow cytometry inflammatory reaction |
| 基金项目:河北省中医药管理局科研计划项目（2014145D） |
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| 中文摘要: |
| 摘 要：［目的］ 探讨胃癌患者围手术期应用莪术油注射液的作用及意义。［方法］ 将80例确诊为胃癌并行肿瘤切除手术的患者分为研究组和对照组，每组40例。研究组术前3天开始给予莪术油葡萄糖注射液0.2g 1次/d，至手术后第6d，共给药10d；对照组给予等量葡萄糖注射液。流式细胞术（FCM）检测2组手术后肿瘤细胞周期和凋亡情况；术前及术后第7d检测两组患者血清炎性因子白细胞介素-2（IL-2）、肿瘤坏死因子-α（TNF-α）、C反应蛋白（CRP）的水平。［结果］ 两组患者的各项临床数据均无明显差异（P>0.05），研究组无药物相关性不良反应。研究组胃癌细胞G0/G1期比率明显高于对照组，S期细胞的比率低于对照组；研究组肿瘤细胞凋亡率明显高于对照组（均P<0.05）。两组患者术前血清IL-2、TNF-α、CRP的水平无明显差异（P>0.05）；术后第7d研究组患者血清IL-2、TNF-α、CRP水平均明显低于对照组（P<0.05）。［结论］ 莪术油注射液可抑制胃癌细胞生长、促进凋亡，并可减轻手术导致的炎症反应。 |
| 英文摘要: |
| Abstract：［Purpose］ To investigate the clinical significance of Zcdoary Turmeric oil injection in application for perioperative patients with gastric cancer. ［Methods］ Eighty cases with gastric cancer undergoing gastrectomy were divided into 2 groups(40 cases in each group). The study group accepted Zcdoary Turmeric oil and glucose injection(0.2g once a day) for 10 days(from 3d preoperation to 6d postoperation)，and control group accepted equal glucose injection. Cell cycle，apoptotic rate were tested with flow cytometry(FCM). And serum IL-2，TNF-α，C reactive protein(CRP ) levels were tested preoperatively and the 7th day postoperation in both groups. ［Results］ There was no significant difference between 2 groups about clinical data(P>0.05)，and no obvious toxicity was observed in study group. Ratio of cells in G0/G1 phase of study group was higher than that of control group，whereas ratio of cells in S phase of study group was lower than that of control group；apoptotic rate of tumor cells in study group was higher than that in control group(P<0.05). There was no obvious difference in levels of IL-2，TNF-α，CRP between 2 groups preoperatively(P>0.05)，while levels of IL-2，TNF-α，CRP in study group were lower than those in control group in the 7th day postoperation(all with P<0.05). ［Conclusion］ Zcdoary Turmeric oil could inhibit growth and promote apoptosis of gastric cancer cells，also it could relieve postoperative inflammatory reaction. |
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