| 潘雪峰,郑国宝,邢红雨.肝动脉化疗栓塞联合伽玛刀治疗原发性肝癌的临床观察[J].肿瘤学杂志,2015,21(4):311-315. |
| 肝动脉化疗栓塞联合伽玛刀治疗原发性肝癌的临床观察 |
| Clinical Observation of Transcatheter Arterial Chemoembolization Combined with Gamma Knife in the Treatment for Primary Liver Cancer |
| 投稿时间：2014-03-18 |
| DOI：10.11735/j.issn.1671-170X.2015.04.B011 |
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| 中文关键词: 肝肿瘤 肝动脉化疗栓塞 伽玛刀 |
| 英文关键词:liver neoplasms transcatheter arterial chemoembolization gamma knife |
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| 摘要点击次数: 1834 |
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| 中文摘要: |
| 摘 要：［目的］ 探讨肝动脉化疗栓塞（TACE）联合伽玛刀治疗原发性肝癌的疗效和不良反应。［方法］ 将2010年1月至2012年12月期间收治的原发性肝癌患者84例分为两组，联合治疗组共计47例患者，先给予TACE治疗，之后给予伽玛刀治疗，伽玛刀照射剂量以50%剂量线作为处方剂量，3~10Gy/次，总剂量40~60Gy，1~3周完成治疗；TACE治疗组共计37例患者，仅给予TACE治疗。［结果］ 联合治疗组和TACE治疗组总有效率分别为80.9%和51.3%，1年生存率分别为74.5%、45.9%，差异均有统计学意义（P＜0.05）；联合治疗组不良反应发生率稍高于TACE治疗组，但差异无统计学意义（P>0.05）。［结论］ 肝动脉化疗栓塞联合伽玛刀治疗原发性肝癌近期疗效满意且并发症发生率低，是中晚期肝癌患者安全有效的治疗方法之一。 |
| 英文摘要: |
| Abstract：［Purpose］ To investigate the efficacy and toxicity of transcatheter arterial chemoembolization(TACE) combined with gamma knife in the treatment for primary liver cancer (PLC). ［Methods］ A total of 84 patients with PLC were enrolled and divided into two groups：combined therapy group(47 patients) and TACE therapy group(37 patients). Combined therapy group were treated with TACE followed by gamma knife.The PTV was covered by the 50% isodose line as prescription dose. The fractional dose was 3~10Gy，and the total dose was 40~60Gy during 1~3 weeks. TACE therapy group were treated with TACE alone．［Results］ The overall response rates of combined therapy group and TACE therapy group were 80.9% and 51.3%，respectively. The 1-year survival rates were 74.5% and 45.9%，respectively，all with significant difference(P<0.05).The side effect were tolerable in the two groups.［Conclusion］ TACE combined with gamma knife could improve the response rate and survival rate of PLC with low toxicity. It is a safe and reliable treatment option for PLC. |
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