| 金瑞英,周坚红.宫颈细胞学阴性患者高危型HPV含量与CIN2及更高级别病变的相关性[J].肿瘤学杂志,2015,21(3):233-236. |
| 宫颈细胞学阴性患者高危型HPV含量与CIN2及更高级别病变的相关性 |
| Relationship Between High-risk Human Papillomavirus and CIN 2 or High Grade in Patients with Negative Cervical Cytology |
| 投稿时间：2014-06-16 |
| DOI：10.11735/j.issn.1671-170X.2015.03.B014 |
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| 中文关键词: 宫颈上皮内瘤变 人乳头状瘤病毒 液基细胞学 |
| 英文关键词:cervical intraepithelial neoplasia human papillomavirus liquid-based cytology |
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| 中文摘要: |
| 摘 要：［目的］ 探讨高危型人乳头状瘤病毒（HPV）检测对宫颈液基细胞学阴性妇女宫颈上皮内瘤变（CIN）的诊断价值。［方法］ 收集宫颈癌筛查中细胞学阴性而高危型HPV阳性的妇女498例，行阴道镜下宫颈活检。分析高危型HPV负荷量与CIN2+的相关性。［结果］ 在498例患者中，CIN2+病变者共65例，占13.1%。高危型HPV<10的257例中患CIN2+有13例，占5.1%。高危型HPV10~100和>100的病例中患CIN2+比例分别为18.2%（26/143）和26.5%（26/98）。各组之间的CIN2+比例差异有统计学意义（χ2=93.673，P=0.000）。在调整年龄因素后，高危型HPV 10~100患CIN2+的风险是<10者的2.356倍（95%CI：1.449~8.828），而>100者患CIN2+的风险是<10者的3.595倍（95%CI：2.214~13.533）。［结论］ 高危型HPV负荷量与CIN病变级别密切相关，高危型HPV负荷量越高，患CIN2+的危险度越高。 |
| 英文摘要: |
| Abstract：［Purpose］ To investigate the value of high-risk human papillomavirus(HR-HPV) in the diagnosis for cervical intraepithelial neoplasia(CIN) with negative liquid-based cytology． ［Methods］ A total of 498 women with positive HR-HPV and negative cytology were enrolled． All cases underwent colposcopic guided biopsy．The relationship of the load of HR-HPV and CIN2 or worse was analyzed.［Results］ Of 498 patients，65 patients were CIN2+ lesions，accounting for 13.1%. The ratio of CIN2+ was 5.1% in HR-HPV<10 group，while it was 18.2%（26/143）in HR-HPV10～100 group and 6.5%（26/98）in HR-HPV>100 group，with significant difference among the 3 groups(χ2=93.673，P=0.000). After adjustment of the age，the risk of CIN2+ in patients with HR-HPV 10～100 was higher that that in patients with HR-HPV<10(OR=2.356，95%CI：1.449～8.828），while the risk of CIN2+ in patients with HR-HPV >100 was higher than that in patients with HR-HPV<10(OR=3.595，95%CI：2.214～13.533）.［Conclusions］ The load of HR-HPV closely relates to grade of CIN. The higher the load of HR-HPV，the higher the risk of of CIN2+. |
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