齐雪军,赵亚玲,付建珠.非霍奇金淋巴瘤中PTEN、VEGF表达水平及微血管密度的研究[J].肿瘤学杂志,2015,21(3):223-227. |
非霍奇金淋巴瘤中PTEN、VEGF表达水平及微血管密度的研究 |
Expressions of PTEN,VEGF and Microvessel Density in Non-Hodgkin’s Lymphoma |
投稿时间:2014-07-29 |
DOI:10.11735/j.issn.1671-170X.2015.03.B012 |
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中文关键词: 非霍奇金淋巴瘤 PTEN VEGF 微血管密度 免疫组织化学。 |
英文关键词:non-Hodgkin’s lymphoma(NHL) PTEN VEGF microvessel density(MVD) immunohistochemistry |
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中文摘要: |
摘 要:[目的] 研究非霍奇金淋巴瘤(non-Hodgkin’s lymphoma,NHL)组织中PTEN、VEGF表达水平及微血管密度(microvessel density,MVD),分析它们之间的相关性。[方法] 运用免疫组化方法检测NHL组织中PTEN、VEGF的表达水平及CD105标记的MVD,同时将反应性淋巴结增生(reactive lymphoid hyperplasia,RLH)病例作为对照。[结果] NHL中PTEN表达水平(31.5%)显著低于RLH组(70.0%)(P<0.05),而VEGF表达水平与MVD均显著高于RLH组(P<0.05);在不同病理分型和不同临床分期的NHL患者中,VEGF、PTEN和MVD的差异均有统计学意义(P均<0.05);PTEN与VEGF和MVD均呈负相关关系。[结论] NHL中PTEN表达的减低及VEGF表达的升高,可促进肿瘤血管新生,进而促进NHL的发展及转移。 |
英文摘要: |
Abstract:[Purpose] To investigate the expressions of PTEN and VEGF and microvessel density (MVD) in non-Hodgkin’s lymphoma(NHL)and to analyze the correlation among them. [Methods] Immunohistochemistry was used to detect PTEN and VEGF expressions and MVD labeled by CD105 in NHL patients,and reactive lymphoid hyperplasia (RLH)group was set as a control. [Results] Expression of PTEN (31.5%) in NHL group was significantly lower than that in RLH group(70.0%)(P<0.05);while expression of VEGF and MVD in NHL group were both significantly higher than those in RLH group(P<0.05).There was significant difference of VEGF,PTEN or MVD in NHL patients with different pathological type or with different clincal stage(P<0.05).PTEN was negatively correlated with both VEGF and MVD. [Conclusion] Low expression of PTEN and high expression of VEGF in NHL might promote angiogenesis, progression and metastasis of NHL. |
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