| 黄仁华,侯艳丽,徐 欣.脑胶质瘤术后三维适形放疗联合替莫唑胺疗效分析[J].肿瘤学杂志,2015,21(3):219-222. |
| 脑胶质瘤术后三维适形放疗联合替莫唑胺疗效分析 |
| Effect of Postoperative Three-dimensional Conformal Radiotherapy and Temozolomide for Glioma |
| 投稿时间：2014-06-12 |
| DOI：10.11735/j.issn.1671-170X.2015.03.B011 |
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| 中文关键词: 脑胶质瘤 三维适形放疗 替莫唑胺 |
| 英文关键词:glioma 3-dimensional conformal radiotherapy temozolomide |
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| 摘要点击次数: 2180 |
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| 中文摘要: |
| 摘 要：［目的］ 探讨脑胶质瘤术后三维适形放疗联合替莫唑胺临床疗效。［方法］ 回顾性分析了84例脑胶质瘤患者，放化疗联合组44例，单纯三维适形放疗组40例，放疗剂量均为60Gy/30F，放化疗联合组口服替莫唑胺。［结果］放化疗联合组和单纯放疗组的中位生存时间（MST）分别为 27个月和 17个月，中位无进展生存时间（mPFS）分别为 16个月和 13个月，P值分别为0.04和0.13。放化疗联合组1、3年生存率分别为58.57%和23.65 %，单纯放疗组1、3年生存率分别为50.45%和19.54%，放化疗联合组的1年、3年生存率均优于单纯放疗组，两组1年生存率差异有统计学意义（P=0.03）。［结论］ 放化疗联合较单纯三维适形放疗能提高脑胶质瘤术后患者总体生存时间及无进展生存时间。 |
| 英文摘要: |
| Abstract：［Purpose］ To investigate the efficacy of temozolomide(TMZ) and 3-dimensional conformal radiotherapy(3D-CRT) in the treatment for postoperative glioma patients.［Methods］ A total of 84 postoperative glioma patients were randomly divided into two groups：TMZ plus 3D-CRT group(radiochemotherapy group，44 cases) and 3D-CRT alone group(40 cases).All patients received 60Gy in 30 fractions，and patients in radiochemotherapy group took TMZ orally.［Results］ The median survival time(MST) in radiochemotherapy group and 3D-CRT alone group was 27 and 17 months respectively，and the median progression free survival (mPFS) was 16 and 13 months respectively，with P value of 0.04 and 0.13 respectively. The 1- and 3-year survival rates in radiochemotherapy group were 58.57% and 23.65%，which were superior to those in 3D-CRT alone group(50.45% and 19.54%).And there was significant difference in 1-year survival between the two groups（P=0.03）.［Conclusion］ Compared with 3D-CRT alone，combination of radiotherapy and chemotherapy might increase overall survival and progression free survival of patients with glioma postoperation. |
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