| 初 平,鲁 洁,金雅琼.随机尿高香草酸/肌酐(HVA/Cr)检测用于神经母细胞瘤诊断的Meta分析[J].肿瘤学杂志,2015,21(3):212-218. |
| 随机尿高香草酸/肌酐(HVA/Cr)检测用于神经母细胞瘤诊断的Meta分析 |
| Meta-analysis on the Value of Homovanillic Acid/Creatinine (HVA/Cr) at Random Urine Collection in the Diagnosis of Neuroblastoma |
| 投稿时间：2014-07-29 |
| DOI：10.11735/j.issn.1671-170X.2015.03.B010 |
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| 中文关键词: 高香草酸(HVA) 肌酐(Cr) 神经母细胞瘤 诊断 Meta分析 |
| 英文关键词:homovanillic acid creatinine neuroblastoma diagnosis Meta analysis |
| 基金项目:国家自然科学基金主任基金项目（81342002）；北京市科委首都市民健康培育项目（Z131100006813044） |
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| 中文摘要: |
| 摘 要：［目的］ 评估随机尿高香草酸与肌酐比值(HVA/Cr)在神经母细胞瘤诊断中的价值。［方法］ 通过对Medline、EMbase、中国期刊全文数据库、中国科技期刊全文数据库、万方数据库进行系统检索，对尿HVA/Cr在神经母细胞瘤诊断中应用的文献进行Meta分析。［结果］ 神经母细胞瘤组随机尿HVA/Cr比值明显显高于健康对照组，差异有统计学意义。随机尿HVA/Cr用于诊断神经母细胞瘤的汇总敏感性为0.81(95%CI：0.76～0.85)，汇总特异性为0.97(95%CI：0.96～0.97)，汇总受试者工作特征曲线（SROC）曲线下面积（AUC）为0.9246。［结论］ 随机尿HVA/Cr用于诊断神经母细胞瘤的敏感性和特异性都较高，具有较高的诊断应用价值。 |
| 英文摘要: |
| Abstract：［Purpose］ To assess the value of homovanillic acid/creatinine (HVA/Cr) at random urine collection for the diagnosis of neuroblastoma.［Methods］ Database including CNKI，VIP Information，Wanfangdata，Medline and EMbase were searched，and literatures on the HVA/Cr in the diagnosis of neuroblastoma were analyzed by Meta-analysis.［Results］ The level of HVA/Cr at random urine collection was significantly higher in the neuroblastoma patients than that in the control group. The pooled sensitivity and pooled specificity of HVA/Cr in the diagnosis of neuroblastoma were 0.81(95%CI：0.76～0.85) and 0.97(95%CI：0.96～0.97) respectively，and the area under the curve(AUC) of summary receiver operating characteristic (SROC) was 0.9246.［Conclusion］ The sensitivity and specificity on HVA/Cr at random urine collection in the diagnosis of neuroblastoma are both at a high level. Thus，HVA/Cr is a good biomarker for diagnosis of neuroblastoma. |
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