| 谷传文,王 姗,郑金华.声动力疗法刺激肿瘤微环境中CD80与CD86表达的研究[J].肿瘤学杂志,2015,21(3):201-205. |
| 声动力疗法刺激肿瘤微环境中CD80与CD86表达的研究 |
| Sonodynamic Therapy Facilating Expression of CD80 and CD86 in Tumor Microenvironment |
| 投稿时间：2014-10-30 |
| DOI：10.11735/j.issn.1671-170X.2015.03.B008 |
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| 中文关键词: 声动力治疗 B16F10细胞 肿瘤微环境 |
| 英文关键词:sonodynamic therapy melanoma B16F10 cells tumor microenvironment |
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| 中文摘要: |
| 摘 要：［目的］ 检测声动力治疗（ sonodynamic therapy，SDT）对B16F10荷瘤鼠模型中肿瘤微环境T细胞共刺激分子CD80、CD86表达情况的影响。［方法］ 以2.0W/cm2超声强度结合250mg/kg 5-氨基酮戊酸（5-ALA）治疗B16F10荷瘤鼠，测量不同实验组小鼠体重及肿瘤大小；免疫组织化学方法检测移植瘤微环境中CD80、CD86、IFN-γ和TNF-α表达情况。［结果］ 与其他组相比，SDT组肿瘤体积缩小更加显著，体重变化无差异；SDT组CD80、CD86、IFN-γ和TNF-α均出现表达增高，且具有统计学意义。［结论］ SDT能够加强T细胞共刺激分子的CD80、CD86的表达，促进抗肿瘤免疫的发生。 |
| 英文摘要: |
| Abstract：［Purpose］ To detect the variation of costimulatory molecules CD80 and CD86 in tumor microenvironment by sonodynamic therapy(SDT) in B16F10 tumor-bearing nude mice. ［Methods］ 2W/cm2 ultrasound intensity with 250mg/kg 5-Aminolevulinic acid （5-ALA）were used in B16F10 tumor-bearing nude mice，and the tumor volume and body weight of mice were measured in different groups respectively before and after treatment.CD80，CD86，IFN-γ and TNF-α in tumor microenvironment were detected by immunohistochemistry. ［Results］ Compared with other groups，variation of tumor volume in SDT group was statistically significant，while variation of body weight in SDT group was not significant；and expressions of CD80，CD86，IFN-γ and TNF-α in SDT group increased significantly.［Conclusion］ SDT facilitates costimulatory molecules CD80 and CD86 secretion and promotes anti-tumor immunity. |
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