| 陈 猛,郭文杰,宗 丹.局部晚期鼻咽癌血浆EBV-DNA水平与肿瘤负荷及预后的关系[J].肿瘤学杂志,2015,21(3):190-194. |
| 局部晚期鼻咽癌血浆EBV-DNA水平与肿瘤负荷及预后的关系 |
| The Relation of Plasma EBV-DNA Level with Tumor Burden and Prognosis in Patients with Locally Advanced Nasopharyngeal Carcinoma |
| 投稿时间：2014-11-20 |
| DOI：10.11735/j.issn.1671-170X.2015.03.B006 |
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| 中文关键词: 鼻咽肿瘤 EB病毒 调强放疗 肿瘤负荷 预后 |
| 英文关键词:nasopharyngeal neoplasms Epstein-Barr virus (EBV) intensity modulated radiation therapy (IMRT) tumor burden prognosis |
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| 中文摘要: |
| 摘 要：［目的］探讨局部晚期鼻咽癌患者治疗前血浆EBV-DNA水平与肿瘤负荷及预后的关系。［方法］ 165例初治局部晚期鼻咽癌患者，均采用适形调强放射治疗（IMRT）。收集患者治疗前EBV-DNA拷贝数水平及肿瘤靶区体积，并对患者生存结果进行随访总结。［结果］ 治疗前血浆EBV-DNA中位拷贝数3790copies/ml，鼻咽原发灶（GTVnx）、淋巴结病灶（GTVnd）及总GTV体积中位值分别为72.46、23.26、106.25cm3；EBV-DNA水平与GTVnd及总GTV体积显著相关（P<0.01）。治疗前血浆EBV-DNA表达阴性及阳性患者2年总生存率分别为100.0%和98.4%（P>0.05），无病生存率94.4%和80.8%（P<0.05）。［结论］ 局部晚期鼻咽癌患者治疗前血浆EBV-DNA水平与鼻咽癌患者颈部淋巴结转移负荷有关，治疗前血浆EBV-DNA表达阴性的患者无病生存率优于阳性患者。 |
| 英文摘要: |
| Abstract：［Purpose］ To investigate relation of pretreatment plasma concentration of Epstein-Barr virus (EBV) DNA with tumor burden and prognosis of patients with locally advanced nasopharyngeal carcinoma (NPC).［Methods］ One hundred and sixty-five patients with locally advanced NPC were treated with IMRT. Blood samples were collected and EBV-DNA was detected by real-time quantitative PCR. The tumor target region was delineated on CT images with IMRT planning system based on MRI images，and the tumor volume was calculated by computer software system summation method. Patients were followed up and survival was analyzed. ［Results］ The median plasma EBV-DNA before treatment was 3790 copies/ml. The median GTVnx、GTVnd and gross GTV were 72.46，23.26，and 106.25cm3 respectively.The relationship between plasma EBV-DNA and GTVnd or gross GTV was positively correlated(P<0.01). The overall survival rate was 100.0% and 98.4%（P>0.05），and the disease-free survival rate was 94.4% and 80.8%（P<0.05）respectively in plasma EBV-DNA negative and positive patients. ［Conclusion］ Plasma EBV-DNA before treatment is an effective predicative factor that reflects the tumor burden of lymph node. The prognosis of patients with plasma EBV-DNA negative expression is better than that of patients with positive expression. |
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