| 吴晨彬,叶秀芳,吴君心.鼻咽癌放射治疗对海马结构相关认知功能影响的研究[J].肿瘤学杂志,2015,21(3):175-178. |
| 鼻咽癌放射治疗对海马结构相关认知功能影响的研究 |
| Influence of Intensity Modulated Radiotherapy on Hippocampal Formation Related Neurocognitive Function in Nasopharyngeal Carcinoma Patients |
| 投稿时间：2014-11-11 |
| DOI：10.11735/j.issn.1671-170X.2015.03.B003 |
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| 中文关键词: 鼻咽肿瘤 海马结构 认知功能 调强放疗 |
| 英文关键词:nasopharyngeal neoplasms hippocampal formation neurocognitive function intensity modulated radiotherapy(IMRT) |
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| 摘要点击次数: 2009 |
| 全文下载次数: 971 |
| 中文摘要: |
| 摘 要：［目的］ 分析鼻咽癌调强放疗对海马结构相关的认知功能的影响。［方法］ 利用韦氏成人记忆力量表中的敏感项目对51例鼻咽癌放疗后1年患者（分为T1~2组和T3~4组）行记忆力相关的神经认知功能检测，同时比较相匹配的鼻咽癌放疗前患者和健康人各30例的各项记忆力检测结果差异。［结果］记忆力相关的神经认知功能检测显示：放疗后T1~2期组和T3~4期组除“数字广度—逆向”无显著差异外，其余各项均有统计学意义，T3~4组患者的认知功能明显低于T1~2期组；鼻咽癌放疗前患者和健康人在联想学习、数字累加、数字广度、视觉再生方面检测结果差异无统计学意义。［结论］ 鼻咽癌调强放疗可导致海马结构功能相关的认知功能损害，特别在T3~4期放疗病例中值得关注。 |
| 英文摘要: |
| Abstract：［Purpose］To investigate the influence of intensity modulated radiotherapy（IMRT) on hippocampal formation related neurocognitive function in nasopharyngeal carcinoma（NPC) patients. ［Methods］ Sensitive items of Wechsler Adult Memory Scale were used to evaluate the neurocognitive function related with memory in 51 patients one year after radiotherapy，and to compare the differences of the memory test results between the pre-radiotherapy group（n=30) and healthy group（n=30). ［Results］ The test results of the neurocognitive function related with memory showed that，for associative learning(AL)，accumulation，digit span(DS) and visual reproduction（VR)，there were no difference between pre-radiotherapy group and healthy group；while they were statistically different between T3～4 stage group and T1～2 stage group，except DS. And the neurocognitive function was lower in T3～4 stage group than that in T1～2 stage group. ［Conclusion］ IMRT in NPC patients might induce hippocampal formation related cognitive function impairment，special attention should be paid in radiotherapy patients with stage T3～4. |
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