| 陈 猛,何 侠.西妥昔单抗治疗鼻咽癌的研究进展[J].肿瘤学杂志,2015,21(3):165-170. |
| 西妥昔单抗治疗鼻咽癌的研究进展 |
| Progress in the Treatment of Nasopharyngeal Carcinoma with Cetuximab |
| 投稿时间：2014-11-19 |
| DOI：10.11735/j.issn.1671-170X.2015.03.B001 |
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| 中文关键词: 西妥昔单抗 鼻咽肿瘤 放射疗法 药物疗法 |
| 英文关键词:cetuximab nasopharyngeal neoplasms radiotherapy drug therapy |
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| 中文摘要: |
| 摘 要：鼻咽癌表皮生长因子受体（EGFR）过表达与不良预后相关，西妥昔单抗竞争性阻断EGFR与配体结合，阻断酪氨酸激酶磷酸化及下游胞内信号通路活化，发挥抗肿瘤作用。西妥昔单抗联合放、化疗用于治疗局部晚期及复发转移性鼻咽癌，耐受性良好，近期疗效显著，不良反应可控。在现有研究证据上应设计有针对性的临床研究，以确定西妥昔单抗与放、化疗的合理联合模式，进一步提高鼻咽癌疗效。该文就西妥昔单抗的作用机制及其用于鼻咽癌治疗的研究现状和进展进行综述。 |
| 英文摘要: |
| Abstract：EGFR overexpression in nasopharyngeal carcinoma is related with poor prognosis ，cetuximab has anti-tumor effect by competitive blocking EGFR ligand binding，tyrosine kinase phosphorylation and downstream intracellular signaling pathway. Treatment with cetuximab combined with radiotherapy and chemotherapy in locally advanced or metastatic nasopharyngeal carcinoma is well tolerable，effective and controllable. Clinical studies should be designed to determine the reasonable treatment mode of cetuximab，radiotherapy and chemotherapy to further improve the efficacy of nasopharyngeal carcinoma，based on the existing evidence. The mechanism of cetuximab and its progress in the treatment of nasopharyngeal carcinoma are reviewed. |
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