| 王宏波,郭存丽,程 文.肝细胞癌患者病灶局部Treg细胞分析及其临床意义[J].肿瘤学杂志,2015,21(2):133-137. |
| 肝细胞癌患者病灶局部Treg细胞分析及其临床意义 |
| Analysis of Treg Cells in Hepatocellular Carcinoma and Their Clinical Significance |
| 投稿时间：2014-06-20 |
| DOI：10.11735/j.issn.1671-170X.2015.02.B012 |
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| 中文关键词: 肝肿瘤 肿瘤浸润淋巴细胞 调节性淋巴细胞 免疫 |
| 英文关键词:hepatocellular neoplasms tumor-infiltrating lymphocytes regulatory T cells immune |
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| 摘要点击次数: 2089 |
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| 中文摘要: |
| 摘 要：［目的］ 探讨肝细胞癌患者病灶局部Treg细胞的变化规律及其临床意义。［方法］ 收集40例原发性肝细胞型肝癌（HCC）患者经手术切除的肝癌组织及非癌肝组织(距肿瘤边缘>5cm)标本，用流式细胞仪分别检测肝癌组织、非癌肝组织中调节性T淋巴细胞（Treg细胞）的 数量及变化规律，并且分析Treg细胞表达数量与预后的关系。［结果］ 肝癌病灶局部有不同程度免疫细胞浸润，主要为T淋巴细胞，其中Treg淋巴细胞含量高于非肿瘤组织。Ⅲ、Ⅳ期患者Treg细胞含量（7.7%±4.03%）明显高于Ⅰ、Ⅱ期患者（3.7%±1.6%）（P=0.037）。高Treg细胞含量组（≥6%）患者的预后明显差于低Treg细胞含量组（＜6%）（P=0.005）。 ［结论］ 肝癌组织中，对免疫起抑制作用的Treg细胞比例增加。Treg细胞含量高与预后差相关。 |
| 英文摘要: |
| Abstract：［Purpose］ To investigate Treg cells in HCC tissue and non-tumor tissue and to evaluate the relationships between the changes of these cells and the prognosis of HCC patients. ［Methods］ Treg cells were isolated from HCC tissue and the corresponding non-tumor tissue and were detected by flow cytometric analysis. We analyzed the relationship between changes of the cells and the clinical data，also between changes of the cells and prognosis. ［Results］ Compared with the non-tumor tissue，TILs had the higher intensity of the CD4+CD25+Foxp3+regulatory T cell’s (Treg cells) infiltration compared with NILs. The intensity of Treg cells in patients stageⅢ，Ⅳ (7.7%±4.03%)was higher than that in patients stageⅠ，Ⅱ(3.7%±1.6%)(P=0.037). The prognosis was worse in high intensity of Treg cells group(≥6%) than that in low intensity of Treg cells group(＜6%)(P=0.005). ［Conclusion］ The ratio of Treg cells increases in tumor tissue of HCC and it correlates with patients’ survival. |
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