| 秦 燕,王肖力.Livin、Beclin-1在子宫内膜癌中的表达及临床意义[J].肿瘤学杂志,2015,21(2):128-132. |
| Livin、Beclin-1在子宫内膜癌中的表达及临床意义 |
| Expression of Livin，Beclin-1 in Endometrial Carcinoma and Its Clinical Significance |
| 投稿时间：2014-07-03 |
| DOI：10.11735/j.issn.1671-170X.2015.02.B011 |
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| 中文关键词: 子宫内膜癌 Livin Beclin-1 免疫组织化学 |
| 英文关键词:endometrial carcinoma Livin Beclin-1 immunohistochemistry |
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| 中文摘要: |
| 摘 要：［目的］ 探讨Livin、Beclin-1 在子宫内膜癌中的表达及其临床意义。［方法］ 选择各类子宫内膜组织蜡块143 例。以免疫组化法检测Livin和Beclin-1的表达并分析其与组织学分级、临床分期以及淋巴结转移等的关系。［结果］ Livin和Beclin-1 表达在不同子宫内膜癌组织中差异均有统计学意义（P<0.05）。Livin和Beclin-1表达与组织学分级和肌层浸润有关（P<0.05），而与FIGO分期和淋巴结转移无关（P>0.05）。［结论］ Livin和Beclin-1 在子宫内膜癌发生和演化及浸润转移中可能起重要作用。 |
| 英文摘要: |
| Abstract：［Purpose］ To investigate the expression of Livin and Beclin-1 in endometrial cancer and their clinical significance.［Methods］ A total of 143 cases of paraffin-embeded endometrial tissues were enrolled. Immunohistochemical method was used to detect expression of Livin and Beclin-1. The relationships between expression of Livin，Beclin-1 and clinical pathological factors were analyzed. ［Results］ Livin and Beclin-1 expression in endometrial carcinoma tissues were significantly different(P<0.05). Expressions of Livin and Beclin-1 related to histological grade and myometrial invasion(P<0.05)，but didn’t relate to FIGO stage and lymph node metastasis(P>0.05).［Conclusion］ Livin and Beclin-1 might play important roles in the carcinogenesis and progress of endometrial cancer. |
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