| 郑学民,马艳培,王 敏.Cables在子宫内膜癌中的表达缺失及意义[J].肿瘤学杂志,2015,21(1):48-50. |
| Cables在子宫内膜癌中的表达缺失及意义 |
| Loss Expression of Cables in Endometrial Cancer and Its Significance |
| 投稿时间：2014-07-30 |
| DOI：10.11735/j.issn.1671-170X.2015.01.B011 |
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| 中文关键词: 子宫内膜癌 Cables 复发 预后 |
| 英文关键词:endometrial cancer Cables recurrence prognosis |
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| 中文摘要: |
| 摘 要：［目的］ 探讨Cables在子宫内膜癌组织中的表达及意义。［方法］ 免疫组化法检测79例子宫内膜癌患者组织中Cables的表达，并进行生存分析。［结果］ Cables在子宫内膜癌中表达缺失与患者年龄、TNM分期、肿瘤分化、淋巴转移无显著相关性，但与复发有显著相关性（r=0.231，P=0.042），COX比例风险回归分析显示Cables是子宫内膜癌预后的独立影响因素（P=0.024），相比Cables阳性表达患者，Cables表达缺失的患者复发率高，中位生存期明显缩短（22个月vs 45个月，P<0.01）。［结论］ Cables参与了子宫内膜癌的发生发展过程，是子宫内膜癌患者独立的预后影响因素。 |
| 英文摘要: |
| Abstract: ［Purpose］To investigate the expression of Cables in endometrial cancer and its significance.［Methods］ The expression of Cables in endometrial cancer tissues was detected immunohistochemically. And survival of the patients was analyzed.［Results］ Loss expression of Cables wasn’t significantly related to age，TNM stage，tumor differentiation and lymph node metastasis，but significantly correlated with tumor recurrence(r=0.231，P=0.042). Compared patients with positive Cables expression，the patients with negative Cables expression had a higher recurrence rate and a shortened medium survival(22 months vs. 45 months，P<0.01). COX regression analysis indicated that Cables was a significant independent prognostic factor (P=0.024).［Conclusion］ Cables participates the carcinogenesis of endometrial cancer，and is a significant independent prognostic factor in patients with endometrial cancer. |
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