郑学民,马艳培,王 敏.Cables在子宫内膜癌中的表达缺失及意义[J].肿瘤学杂志,2015,21(1):48-50. |
Cables在子宫内膜癌中的表达缺失及意义 |
Loss Expression of Cables in Endometrial Cancer and Its Significance |
投稿时间:2014-07-30 |
DOI:10.11735/j.issn.1671-170X.2015.01.B011 |
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中文关键词: 子宫内膜癌 Cables 复发 预后 |
英文关键词:endometrial cancer Cables recurrence prognosis |
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中文摘要: |
摘 要:[目的] 探讨Cables在子宫内膜癌组织中的表达及意义。[方法] 免疫组化法检测79例子宫内膜癌患者组织中Cables的表达,并进行生存分析。[结果] Cables在子宫内膜癌中表达缺失与患者年龄、TNM分期、肿瘤分化、淋巴转移无显著相关性,但与复发有显著相关性(r=0.231,P=0.042),COX比例风险回归分析显示Cables是子宫内膜癌预后的独立影响因素(P=0.024),相比Cables阳性表达患者,Cables表达缺失的患者复发率高,中位生存期明显缩短(22个月vs 45个月,P<0.01)。[结论] Cables参与了子宫内膜癌的发生发展过程,是子宫内膜癌患者独立的预后影响因素。 |
英文摘要: |
Abstract: [Purpose]To investigate the expression of Cables in endometrial cancer and its significance.[Methods] The expression of Cables in endometrial cancer tissues was detected immunohistochemically. And survival of the patients was analyzed.[Results] Loss expression of Cables wasn’t significantly related to age,TNM stage,tumor differentiation and lymph node metastasis,but significantly correlated with tumor recurrence(r=0.231,P=0.042). Compared patients with positive Cables expression,the patients with negative Cables expression had a higher recurrence rate and a shortened medium survival(22 months vs. 45 months,P<0.01). COX regression analysis indicated that Cables was a significant independent prognostic factor (P=0.024).[Conclusion] Cables participates the carcinogenesis of endometrial cancer,and is a significant independent prognostic factor in patients with endometrial cancer. |
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