| 赵 林,李金龙,丁界先.S100B蛋白在放射性脑损伤评价中作用的Meta分析[J].肿瘤学杂志,2015,21(1):39-43. |
| S100B蛋白在放射性脑损伤评价中作用的Meta分析 |
| Meta-analysis on the Role of Serum S100B Protein in Evaluation of Radiation-induced Brain Damage |
| 投稿时间：2014-03-31 |
| DOI：10.11735/j.issn.1671-170X.2015.01.B009 |
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| 中文关键词: S100B 放射性脑损伤 Meta分析 |
| 英文关键词:S100B radiation-induced brain injury Meta-analysis |
| 基金项目:甘肃省自然科学研究基金计划（0803RJZA070）；兰州市社会科技发展规划（2009-1-64） |
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| 中文摘要: |
| 摘 要：［目的］ 研究血清S100B蛋白在诊断颅内恶性肿瘤患者放射性脑损伤中的作用。［方法］ 计算机检索中国生物医学文献数据库、中国期刊全文数据库、中文科技期刊全文数据库、万方数据库、PubMed、Embase和The Cochrane Library，纳入S100B蛋白与放射性脑损伤关系的研究，并用RevMan5.2软件进行统计分析。［结果］ 共纳入5篇研究，Meta分析结果显示：接受放疗患者的S100B水平均高于脑胶质瘤患者和脑转移瘤患者的S100B水平（P＜0.05）；接受放疗总剂量5000cGy患者S100B阳性人数少于接受放疗总剂量7000cGy患者S100B阳性人数（P＜0.05）；普通放疗患者的S100B水平高于三维适形或调强放疗，差异有统计学意义（P＜0.05）。［结论］ 血清S100B蛋白可作为颅内恶性肿瘤放射性脑损伤诊断的较早期监测指标。 |
| 英文摘要: |
| Abstract：［Purpose］ To investigate the role of serum S100B protein in the diagnosis for radiation-induced brain damage in patients with brain malignancy.［Methods］ Studies related with S100B protein and radiation-induced brain damage were searched from Chinese Biomedical Literature Database，China Academic Journals，Chinese Journal Full-text Database of Science and Technology，Wanfang Database，PubMed，Embase and The Cochrane Library. RevMan5.2 software was used for Meta-analysis.［Results］ A total of 5 studies were involved. Meta analysis showed ：S100B levels in patients received radiotherapy were higher than those in patients with brain metastases and glioma（P＜0.05）. S100B positive expression patients in total radiation dose of 5000cGy group were less than those in total radiation dose of 7000cGy group（P＜0.05）. S100B levels in patients with conventional radiotherapy were higher than those with three-dimensional conformal radiotherapy or intensity-modulated radiotherapy，with significant difference（P＜0.05）. ［Conclusion］ Serum S100B protein may be used as an indicator for earlier diagnosis of radiation-induced brain damage in patients with malignant brain tumor. |
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