倪 佳.甲状腺乳头状癌与甲状腺结节钙化的关系研究[J].肿瘤学杂志,2014,20(12):1031-1034.
甲状腺乳头状癌与甲状腺结节钙化的关系研究
Relationship Between Papillary Thyroid Carcinoma and Thyroid Nodules with Calcification
投稿时间:2014-07-31  
DOI:10.11735/j.issn.1671-170X.2014.12.B013
中文关键词:  甲状腺结节  甲状腺肿瘤  乳头状癌  超声检查  钙化
英文关键词:thyroid nodule  thyroid neoplasms  papillary carcinoma  ultrasonography  calcification
基金项目:
作者单位
倪 佳 天门市第一人民医院 
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中文摘要:
      摘 要:[目的] 探讨甲状腺结节合并钙化与甲状腺乳头状癌的关系。[方法] 回顾性分析 240例甲状腺结节患者的彩色超声资料与病理诊断结果。[结果] 240例甲状腺结节中,甲状腺良性疾病钙化率为23.3%(38/163),而甲状腺乳头状癌中钙化率达75.3%(58/77),两组差异有统计学意义(χ2=58.947,P<0.001)。钙化诊断甲状腺乳头状癌的ROC曲线下面积为0.811(95%CI:0.750~0.871)。微钙化患甲状腺乳头状癌的风险是非微钙化者的5.348倍(95%CI:2.804~10.200),而粗钙化患甲状腺乳头状癌的风险是非粗钙化者的4.000倍(95%CI:1.564~10.230)。[结论] 钙化尤其是微钙化对于诊断甲状腺癌的特异性较高。当彩超发现甲状腺结节中有微小钙化时应提高警惕,尤其是微钙化,应进一步做针吸细胞学检查。
英文摘要:
      Abstract:[Purpose] To investigate the relationship between thyroid nodules with calcification and papillary thyroid carcinoma(PTC). [Methods] The ultrasonographic and pathological data of 240 patients with thyroid nodules were analyzed retrospectively. [Results] Among 240 patients with thyroid nodules,the rate of calcification in PTC was 75.3%(58/77),and that in benign thyroid nodules was 23.3%(38/163)(χ2=58.947,P<0.001).The area under ROC curve of calcification for diagnosis of PTC was 0.811(95%CI:0.750~0.871). The risk of thyroid nodules with microcalcification(OR=5.348,95%CI:2.804~10.200 ),or with macrocalcification (OR=4.000,95%CI:1.564~10.230) for PTC was higher than that without microcalcification or macrocalcification respectively.[Conclusion] Calcification in thyroid nodule under ultrasound should be vigilant,especially microcalcification,and further fine needle aspiration cytology should be performed.
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