| 倪 佳.甲状腺乳头状癌与甲状腺结节钙化的关系研究[J].肿瘤学杂志,2014,20(12):1031-1034. |
| 甲状腺乳头状癌与甲状腺结节钙化的关系研究 |
| Relationship Between Papillary Thyroid Carcinoma and Thyroid Nodules with Calcification |
| 投稿时间：2014-07-31 |
| DOI：10.11735/j.issn.1671-170X.2014.12.B013 |
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| 中文关键词: 甲状腺结节 甲状腺肿瘤 乳头状癌 超声检查 钙化 |
| 英文关键词:thyroid nodule thyroid neoplasms papillary carcinoma ultrasonography calcification |
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| 中文摘要: |
| 摘 要：［目的］ 探讨甲状腺结节合并钙化与甲状腺乳头状癌的关系。［方法］ 回顾性分析 240例甲状腺结节患者的彩色超声资料与病理诊断结果。［结果］ 240例甲状腺结节中，甲状腺良性疾病钙化率为23.3％(38/163)，而甲状腺乳头状癌中钙化率达75.3%(58/77)，两组差异有统计学意义（χ2=58.947，P<0.001）。钙化诊断甲状腺乳头状癌的ROC曲线下面积为0.811（95%CI：0.750~0.871）。微钙化患甲状腺乳头状癌的风险是非微钙化者的5.348倍（95%CI：2.804~10.200），而粗钙化患甲状腺乳头状癌的风险是非粗钙化者的4.000倍（95%CI：1.564~10.230）。［结论］ 钙化尤其是微钙化对于诊断甲状腺癌的特异性较高。当彩超发现甲状腺结节中有微小钙化时应提高警惕，尤其是微钙化，应进一步做针吸细胞学检查。 |
| 英文摘要: |
| Abstract：［Purpose］ To investigate the relationship between thyroid nodules with calcification and papillary thyroid carcinoma(PTC). ［Methods］ The ultrasonographic and pathological data of 240 patients with thyroid nodules were analyzed retrospectively. ［Results］ Among 240 patients with thyroid nodules，the rate of calcification in PTC was 75.3%(58/77)，and that in benign thyroid nodules was 23.3％(38/163)（χ2=58.947，P<0.001）.The area under ROC curve of calcification for diagnosis of PTC was 0.811（95%CI：0.750～0.871）. The risk of thyroid nodules with microcalcification(OR=5.348，95%CI：2.804～10.200 )，or with macrocalcification (OR=4.000，95%CI：1.564～10.230) for PTC was higher than that without microcalcification or macrocalcification respectively.［Conclusion］ Calcification in thyroid nodule under ultrasound should be vigilant，especially microcalcification，and further fine needle aspiration cytology should be performed. |
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