| 陈鹏程,毛伟敏.初治非小细胞肺癌患者血小板增高与临床病理及预后的关系[J].肿瘤学杂志,2014,20(12):999-1005. |
| 初治非小细胞肺癌患者血小板增高与临床病理及预后的关系 |
| The Correlation of Thrombocytosis with Clinicopathologic Characteristics and Prognosis in Patients with Non-small Cell Lung Cancer Initially Treated |
| 投稿时间：2014-10-09 |
| DOI：10.11735/j.issn.1671-170X.2014.12.B007 |
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| 中文关键词: 癌，非小细胞肺 血小板计数 临床病理学 预后 |
| 英文关键词:non-small cell lung cancer platelet count clinicopathology prognosis |
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| 摘要点击次数: 2032 |
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| 中文摘要: |
| 摘 要：［目的］探讨初治非小细胞肺癌患者血小板增高与临床病理参数及预后的关系。［方法］ 检测初治非小细胞肺癌治疗前血小板计数，其中血小板增高组103例（血小板计数≥400×109/L），随机选择同期收治的血小板正常组100例作为对照，分析血小板增高与患者临床病理参数及预后的关系。［结果］两组患者肿瘤分化程度、临床分期、淋巴结转移情况差异有统计学意义，血小板增高患者分化程度相对差（χ2＝4.140，P＝0.042），临床分期晚(χ2＝4.656，P＝0.031），淋巴结转移患者比例高（χ2＝11.226，P＝0.001）。单因素分析显示病理类型、分化程度、淋巴结转移、临床分期、治疗方式、血小板计数是影响非小细胞肺癌预后的因素，其中血小板增高患者3年生存率为18.2%，明显低于血小板正常患者的39.1%（χ2=10.684，P=0.001）。多因素分析显示分化程度、血小板计数、临床分期是初治非小细胞肺癌患者预后的独立影响因素。［结论］ 血小板增高是初治非小细胞肺癌患者预后不良的独立影响因素。临床医师应特别关注治疗前血小板增高肿瘤患者。 |
| 英文摘要: |
| Abstract：［Purpose］ To investigate the correlation of thrombocytosis with clinicopathologic chara-cteristics and prognosis in patients with non-small cell lung cancer(NSCLC) initially treated.［Methods］ Pre-treatment platelet count was detected in NSCLC patients initially treated，among them there were 103 cases with thrombocytosis(platelet count≥400×109/L)，100 cases with normal platelet count. The correlation of thrombocytosis with clinicopathologic characteristics and prognosis was analyzed.［Results］ There were significant difference of differentiation grade，clinical stage and lymph node metastasis between the two groups，patients with thrombocytosis had worse differentiation（χ2＝4.140，P＝0.042），more advanced stage(χ2＝4.656，P＝0.031）and higher percentage of lymph node metastasis（χ2＝11.226，P＝0.001）. Univariate analysis showed that pathologic type，differentiation grade，lymph node metastasis，clinical stage，treatment modality and platelet count were influencing factors for prognosis of NSCLC patients.The 3-year survival rate of patients with thrombocytosis was 18.2%，which was significantly lower than that in patients with normal platelet count(39.1%)（χ2=10.684，P=0.001）.Multivariate analysis showed that differentiation grade，platelet count and clinical stage were independent prognostic factors for NSCLC patients.［Conclusion］ Thrombocytosis is independent factor for poor prognosis of NSCLC patients initially treated. Pretreatment thrombocytosis should be paid attention to. |
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