| 杨桂春,于丽波,王玉霞.NOB1在宫颈鳞癌中的表达及其临床意义[J].肿瘤学杂志,2014,20(12):990-993. |
| NOB1在宫颈鳞癌中的表达及其临床意义 |
| Expression of NOB1 in Cervical Squamous Cell Carcinoma and Its Clinical Significance |
| 投稿时间：2014-03-23 |
| DOI：10.11735/j.issn.1671-170X.2014.12.B005 |
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| 中文关键词: 宫颈肿瘤 鳞状细胞癌 NOB1 预后 |
| 英文关键词:cervical neoplasms squamous cell carcinoma NOB1 prognosis |
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| 中文摘要: |
| 摘 要：［目的］ 探讨NOB1在宫颈鳞癌组织中的表达及其与临床病理因素和预后的关系。［方法］ 采用免疫组织化学SP法检测157例宫颈鳞癌、54例宫颈上皮内瘤样病变（CIN）及42例宫颈正常组织中NOB1的表达。［结果］宫颈正常组织、CIN组织和宫颈鳞癌组织NOB1的表达阳性率分别为5.0%、29.6%和73.8%，差异有统计学意义(P<0．001)。NOB1在宫颈癌中的表达与肿瘤分化程度及是否淋巴结转移有关(P<0.05)；而与患者年龄、肿瘤直径、临床病理分期及浸润深度无明显相关(P>0.05)。ＮＯＢ１阳性表达患者的５年累积生存率较阴性表达者低(P<0.01)。［结论］ NOB1的表达与宫颈鳞癌的临床病理因素及预后有一定关系，其高表达可能在宫颈癌发生、发展中起重要作用，并很可能成为潜在的治疗靶点及预测宫颈癌预后的有价值的分子标志物。 |
| 英文摘要: |
| Abstract：［Purpose］ To investigate the expression of NOB1 in cervical squamous cell carcinoma and its relationship with clinicopathological features and prognosis.［Methods］ Expression of NOB1 was detected by immunohistochemistry in 157 cases of cervical squamous cell carcinoma，57 cases of cervical intraepithelial neoplasia(CIN) and 42 cases of normal cervical tissue． ［Results］ The positive rates of NOB1 in normal cervical tissues，cervical intraepithelial neoplasia tissues and cervical squamous cell carcinoma tissue were 5.0%，29.6% and 73.8% respectively(P<0．001). The expression level of NOB1 related to tumor differentiation and lymph node metastasis in patients with cervical squamous cell carcinoma (P<0.05)，but didn’t relate to age，tumor size，FIGO stage and tumor infiltration depth(P>0.05). 5-year survival rate in patients with NOB1 positive expression was lower than that in NOB1 negative expression group．［Conclusion］ The high expression of NOB1 may be involved in the carcinogenesis and progression of cervical squamous cell carcinoma.The expression of NOB1 has a certain relationship with clinicopathological factors of cervical squamous cell carcinoma，which is likely to be a potential therapeutic target and valuable prognostic indicator． |
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