| 中文关键词: 脑转移瘤 合理治疗模式 生存期 预后 |
| 英文关键词:brain metastases rational treatment model survival prognosis |
| 基金项目:河北省卫生厅重点科技支撑计划（20110126） |
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| 中文摘要: |
| 摘 要：［目的］ 探讨脑转移瘤患者的合理治疗模式。［方法］ 回顾性分析330例脑转移瘤患者的临床资料，根据不同治疗方法进行分组，比较各组患者的中位生存期；并分析预后的影响因素。［结果］ 综合治疗组与单一治疗组中位生存时间分别为19个月和6个月（P<0.01）。综合治疗组中3种治疗方式联合组与2种治疗方式联合组中位生存时间分别为29个月和12个月（P<0.01）。全身+局部治疗组与局部治疗组中位生存时间分别为21个月和6个月（P<0.01）。在全身+局部治疗组中3种治疗方式联合与2种治疗方式联合中位生存时间分别为29个月和13个月（P<0.01）。分子靶向药物治疗组与非分子靶向治疗组中位生存时间分别为37个月和9个月（P<0.01）。年龄、原发肿瘤病理亚型为影响脑转移瘤患者预后的独立因素。［结论］ 脑转移瘤患者最佳的治疗模式为手术、放疗、化疗3种治疗方式联合治疗。具有分子靶向药物应用指征的患者，在原方案基础上联合分子靶向药物治疗效果更佳，但不同治疗方式的选择时机及联合方式尚需进一步研究。 |
| 英文摘要: |
| Abstract：［Purpose］ To explore the different treatment modes for the patients with brain metastases. ［Methods］ A total of 330 patients with brain metastases were investigated retrospectively. The patients were divided into different groups according to the different treatment measures. Median survival time was compared in different groups and influence factors of prognosis were analyzed. ［Results］ The median survival time was 19 months for combined treatment group，and 6 months for single treatment group(P<0.01). The median survival time was 29 months for systemic and local treatment group，and 12 months for local treatment group (P<0.01). The median survival time was 37 months for molecular targeted treatment group，and 9 months for non molecular targeted treatment group(P<0.01). In systemic and local treatment group，the median survival time was 29 months for the group of three kinds of treatments combined，and 13 months for the group of two kinds of treatments combined (P<0.01). Age and primary tumor pathological subtype were independent factors affecting the prognosis of patients with brain metastases. ［Conclusion］ The reasonable treatment for patients with brain metastases is combined treatment with operation，radiotherapy and chemotherapy. Molecular targeted drugs can be used on the basis of original scheme in patients with application of indications，which could have better therapy effect，but the timing of different treatments and joint way still needs further research. |
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