| 陈 鲁,屠 珏,张英丽.人参皂苷Rg3与顺铂对荷卵巢癌裸鼠免疫功能及肿瘤相关蛋白的影响[J].肿瘤学杂志,2014,20(11):914-919. |
| 人参皂苷Rg3与顺铂对荷卵巢癌裸鼠免疫功能及肿瘤相关蛋白的影响 |
| Effect of Ginsenoside Rg3 and Cisplatin on Immunity and Tumor Related Proteins in Nude Mice Bearing Ovarian Cancer |
| 投稿时间：2014-06-13 |
| DOI：10.11735/j.issn.1671-170X.2014.11.B009 |
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| 中文关键词: 人参皂苷 卵巢肿瘤 裸鼠 顺铂 免疫功能 |
| 英文关键词:ginsenoside ovarian neoplasms nude mice cisplatin immunity |
| 基金项目:浙江省中医药科技计划资助项目(2011ZA015) |
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| 中文摘要: |
| 摘 要：［目的］ 观察人参皂苷Rg3联合顺铂对荷高转移人卵巢癌细胞系HO-8910PM 转移瘤裸鼠白细胞介素-2（IL-2）、干扰素-γ（INF-γ）及nm23、血管内皮生长因子（VEGF）及增殖细胞核抗原（PCNA）的影响。［方法］ 移植瘤裸鼠随机分成6组腹腔给药:荷瘤空白对照组(A组)；不同Rg3浓度药物组：2.5mg/kg(B组)、5mg/kg(C组)和10mg/kg(D组)；Rg3和顺铂联用组(E组)以及顺铂阳性对照组(F组)。分别测定各组裸鼠转移瘤体积变化、IL-2、INF-γ、nm23、VEGF及PCNA的变化情况。［结果］ 与A组比较，E组(P<0.05)和F组(P<0.01)小鼠血清中IL-2、INF-γ含量均能显著降低；B(P<0.05)、C、D和E(P<0.01)组小鼠移植瘤组织nm23的表达均增强。Rg3给药后，小鼠移植瘤组织VEGF、PCNA表达均呈下降趋势。［结论］ 人参皂苷Rg3和顺铂联用具有协同抗肿瘤及减毒的作用。Rg3可能通过增强nm23的表达，使VEGF及PCNA表达呈下降趋势等多途径产生抗肿瘤作用。 |
| 英文摘要: |
| Abstract：［Purpose］ To investigate the effects of ginsengside Rg3 combined with cisplatin on the expression of IL-2，INF-γ，nm23，vascular endothelial growth factor (VEGF) and proliferating cell nuclear antigen (PCNA) in nude mice bearing high-metastasis human ovarian cancer cell line HO-8910PM.［Methods］ Nude mice were randomly divided into 6 groups：tumor-bearing control group(group A)；different concentrations of Rg3 groups：2.5mg/kg(group B)，5mg/kg (group C) and 10mg/kg(group D)；Rg3 and cisplatin group(group E)；cisplatin group(group F). The variantions of IL-2，INF-γ，nm23，VEGF and PCNA in each group were detected. ［Results］Compared with group A，the serum level of IL-2 and INF-γ in group E(P<0.05) and group F(P<0.01) reduced significantly. The expression of nm23 enhanced in the transplanted tumor tissues of group B(P<0.05)， group C，D and E(P<0.01). The expressions of VEGF and PCNA in transplanted tumor tissues decreased after Rg3 administration.［Conclusion］ Ginsenoside Rg3 combined with cisplatin have a synergetic anti-tumor effect and toxicity attenuation. Rg3 might play a role of anti-tumor through multiple pathways including increasing the expression of nm23，declining the expression of VEGF and PCNA，etc. |
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