孙国贵,崔大为,程云杰.前列腺癌中细丝蛋白A表达的临床意义[J].肿瘤学杂志,2014,20(9):751-754. |
前列腺癌中细丝蛋白A表达的临床意义 |
Expression of Filamin A in Prostate Cancer and Its Significance |
投稿时间:2013-09-12 |
DOI:10.11735/j.issn.1671-170X.2014.09.B013 |
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中文关键词: 细丝蛋白A(FLNA) 前列腺肿瘤 预后 肿瘤转移 |
英文关键词:Filamin A(FLNA) prostate neoplasms prognosis neoplasm metastasis |
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中文摘要: |
摘 要:[目的] 探讨细丝蛋白A(filamin A,FLNA)在前列腺癌中的表达及意义。[方法] 采用免疫组织化学方法、Western blot检测68例前列腺癌组织及距其癌组织边缘2cm以上的镜下未见癌浸润的正常组织中FLNA蛋白的表达情况。[结果] 免疫组织化学结果表明,FLNA蛋白在前列腺癌组织的表达阳性率为38.2%,较正常前列腺组织(75.7%)明显降低(P<0.05)。Western blot 结果表明,FLNA 的蛋白在前列腺癌组织的相对表达量较正常前列腺组织明显降低,两者比较差异具有统计学意义(P<0.05)。FLNA蛋白表达与前列腺患者年龄、PSA水平无关(P>0.05);而与淋巴结转移、临床分期以及Gleason评分有关(P<0.05)。[结论] 前列腺癌组织中FLNA蛋白表达明显减低,可能在前列腺癌发生的负反馈调节中起重要作用。 |
英文摘要: |
Abstract:[Purpose]To analyze the expression of filamin A(FLNA) in prostate cancer and its clinical significance. [Methods] FLNA protein expression in 68 cases with prostate cancer and in normal tissues without cancer infiltration which was adjacent to cancer tissue with distance >2cm,was detected by immunohistochemistry and Western blot methods.[Results] Immunohistochemistry result showed that FLNA protein expression was significantly lower in prostate cancer tissue than that in normal tissues (38.2% vs 75.7%,P<0.05). Western blot result showed that the relative amount of FLNA protein in prostate cancer tissue was significantly lower than that in normal tissues(P<0.05). The level of FLNA protein expression was not correlated to age and PSA(P>0.05),but it was correlated to lymph node metastasis,clinical stage and Gleason score(P<0.05). [Conclusion] Low FLNA expression in prostate cancer might play an important role as a negative regulator in prostate carcinogenesis. |
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