| 杨守梅,尉浩兵,李世伟.双铂联合氟尿嘧啶二线治疗复发转移食管癌研究[J].肿瘤学杂志,2014,20(9):739-741. |
| 双铂联合氟尿嘧啶二线治疗复发转移食管癌研究 |
| Nedaplatin and Cisplatin Combined with Fluorouracil as Second-line Therapy for Recurrence and Metastasis of Esophageal Cancer |
| 投稿时间：2014-06-10 |
| DOI：10.11735/j.issn.1671-170X.2014.09.B010 |
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| 中文关键词: 食管肿瘤 复发 肿瘤转移 二线化疗 |
| 英文关键词:esophageal neoplasms recurrence neoplasm metastasis second-line chemotherapy |
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| 中文摘要: |
| 摘 要：［目的］ 观察双铂方案二线治疗复发转移食管癌的近期疗效及不良反应。［方法］ 30例一线化疗后复发转移食管癌患者，进行二线治疗，化疗方案：顺铂25mg/m2 d1，奈达铂25mg/m2 d2，3，氟尿嘧啶0.35g/m2 civ d1~7，3周重复。［结果］ 部分缓解（PR） 11例，疾病稳定（SD） 8例，疾病进展（PD） 11例，有效率（RR）为36.7%，疾病控制率（DCR）为63.3%，中位达进展时间（TTP）为4.3个月（95%CI：1.1～10.5），中位生存时间（MST）为8.9个月（95%CI：2.1～15.3）。主要不良反应为血液学毒性，Ⅲ～Ⅳ级白细胞减少的发生率分别为13.3%，Ⅲ级口腔炎的发生率为6.7%。［结论］ 双铂联合氟尿嘧啶二线治疗复发转移食管癌的近期疗效较好，不良反应可耐受。 |
| 英文摘要: |
| Abstract：［Purpose］ To investigate the efficacy and toxicity of nedaplatin and cisplatin combined with fluorouracil as second-line therapy for recurrence and/or metastasis of esophageal cancer. ［Methods］ Thirty recurrent and/or metastatic esophageal cancer patients failed to first-line chemotherapy were treated with second-line chemotherapy：cisplatin 25mg/m2 d1, nedaplatin 25mg/m2 d2,3, fluorouracil 0.35g/m2 civ d1～7 every 3 weeks.［Results］ The total response rate was 36.7% and the disease control rate was 63.3%, with PR in 11 cases, SD in 8 cases, PD in 11 cases. The median time to progression(TTP) was 4.3 months (95%CI：1.1~10.5), median survival time(MST) was 8.9 months(95%CI：2.1~15.3). The main toxicity was hematologic toxicity, with incidence of neutropenia grade Ⅲ~Ⅳ 13.3%,incidence of stomatitis grade Ⅲ 6.7%. ［Conclusion］ Nedaplatin and cisplatin combined with fluorouracil as second-line therapy for recurrence and metastasis of esophageal cancer is effective and the toxicities are tolerable. |
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