| 中文关键词: 乳腺肿瘤 乳腺癌干细胞 靶向治疗 肿瘤标志物 |
| 英文关键词:breast neoplasms breast cancer stem cells target therapy tumor markers |
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| 中文摘要: |
| 摘 要：乳腺癌干细胞是乳腺肿瘤细胞中少数具有自我更新和分化潜能，并能维持乳腺肿瘤的生长和异质性的一类细胞。越来越多的证据表明，乳腺癌干细胞在乳腺癌的发生、生长、复发、转移和抗药性等方面起决定性的作用。因此，研究乳腺癌干细胞的调控机理和开发靶向乳腺癌干细胞的新药已经成为乳腺癌研究中的热点。文章简要综述乳腺癌干细胞的概念，分离鉴定及其在乳腺癌转移和治疗中的作用，并对其分子调控进行了探讨。 |
| 英文摘要: |
| Abstract：Breast cancer stem cells are a rare group of breast tumor cells with self-renewal and differentiation potential properties，which are essential for the maintenance of breast cancer growth and tumor heterogeneity. Increasing evidence indicates that breast cancer stem cells play a critical role in breast cancer oncogenesis，development，recurrence，metastasis and drug resistance. Hence，study of the mechanisms associated with breast cancer stem cell regulation and developing novel drugs targeting breast cancer stem cells are the hot spots in breast cancer research. This review presents a fundamental introduction of breast cancer stem cell concept，methods for isolation and characterization，the role of stem cells in breast cancer development，metastasis and treatment，and the regulation mechanisms. |
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